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Systemic lupus erythematosus is one of the diseases with a high misdiagnosis rate, which is related to
the non-specificity and fixed pattern of the first symptoms of lupus erythematosus patients, and the variety of clinical manifestations.
01 Early misdiagnosis is often misdiagnosed as rheumatoid arthritis
About 90% of patients with lupus erythematosus have joint swelling and pain, often polyarticular, symmetrical and paroxysmal, very similar to rheumatoid arthritis, joint symptoms can be the earliest manifestation of the disease, or even the only manifestation for a long time, coupled with some patients rheumatoid factor positive, so early is often misdiagnosed as rheumatoid arthritis
.
02 Misdiagnosed as an allergy
Mucocutaneous lesions are one of the most common manifestations of lupus erythematosus, with an incidence of 80%~85%, and typical butterfly erythema accounts for 30%~50%, but more often manifested as various rashes, such as maculopapular rash, urticaria, purpura, periungual erythema, erythema nodosum, livedo reticularis, chilblas-like rash
.
03 Misdiagnosis as kidney disease
Renal damage is the most common and severe manifestation of lupus erythematosus, almost all patients eventually have renal damage, and the deposition of immune complexes in the glomerular basement membrane is the pathological basis
of lupus erythematosus.
04 Misdiagnosed as a digestive disorder
30% of patients may have loss of appetite, abdominal pain, vomiting or diarrhea, vasculitis and certain antibodies can also cause diarrhea, abdominal pain, blood in the stool and other digestive symptoms, 40% of patients have elevated
serum aminotransferases.
However, jaundice generally does not appear, a small number of patients can be complicated by acute abdomen, such as pancreatitis, intestinal necrosis, intestinal obstruction, some patients with the above symptoms are complicated by acute abdomen, if not vigilant, easy to misdiagnose
.
05 misdiagnosis as other system damage
Respitable, circulatory, and neurologic lesions are the first symptoms of common lupus erythematosus, such as serositis due to lupus erythematosus vasculitis, which may present as pleural effusions and pericardial effusions
.
Anti-neurogenic antibodies and lupus erythematosus vasculitis can cause a variety of manifestations of the central and peripheral nervous system, which can be described as diffuse, focal and mixed, common migraine, convulsive seizures and mental abnormalities
.