Luo Wenbo / yuan Tifei's team found the dynamic change of time perception of methamphetamine addicts during withdrawal

Time is one of the most important dimensions of the real world, and human exploration of it has never stopped It is also an eternal topic, philosophers, physicists and so on have been exploring it Time is closely related to the survival and evolution of human beings In ancient times, in order to hunt, human beings must accurately grasp the rules of animals; in order to cultivate, we must understand the changes of the four seasons climate, and need to form a time memory and spread it Nowadays, the time measurement requirements may be higher, for example, the control of various precision instruments, the implementation of precision medicine The reason is that it can not only reveal the mystery of the physical world, but also promote the understanding of human beings Because time is also regarded as the cornerstone of all kinds of cognitive processing [3] In psychological research, many theories put forward the close relationship between time perception and impulse, risk decision-making [4] The brain mechanism of time perception involves the prefrontal striatal loop, motor cortex, midbrain dopamine neuron function, and there are many overlaps with drug addiction brain area [5-7] The activation of reward system can change people's judgment on the speed of time passing outside; the use of long-term addictive drugs may have a continuous impact on the time perception of addicts; however, there is no corresponding systematic study On October 30, 2019, Professor Luo Wenbo's team from Liaoning Normal University, Professor Yuan Tifei's team from Shanghai Mental Health Center and their collaborators published an article on science advanced time perception elicits and its dose-dependent effect in methamphetamine dependents with short-term abstinence to conduct in-depth research on the change of time perception of drug addicts The research team recruited healthy people and methamphetamine (methamphetamine) addicts in different abstinence periods in communities and rehabilitation institutions, and used multiple time replication and comparison tasks at different time intervals to systematically explore the changes of time perception in motor timing and perception timing components of ice addicts, and the relationship between time perception and pre abstinence intake In the first study, 1-5s time replication task was used to investigate motor timing The results showed that the indifference time point of ice addicts in the short-term abstinence period was 1 second ahead of that in the long-term abstinence period and the healthy group, which was a time perceptual violet effect in advance, indicating that the internal clock speed of the short-term abstinence period subjects was faster; the abstinence group had a lower coefficient of variation; and the behavioral indicators of the task were only processed longer than 1 or 2 seconds in the short-term abstinence group There was a significant correlation between the time interval and the amount of intake before abstinence In Study 2, perception timing was measured by time-resolved task in two scales: short-term (200-800 MS) and long-term (1400-2600 MS) Results there was no significant difference in behavioral indicators (subjective equivalency and time sensitivity) between the groups; the amount of pre withdrawal was only negatively correlated with the subjective equivalency under long-term processing, indicating that the greater the amount of pre withdrawal Bingdu, the more likely it was to overestimate the second duration associated with higher cognitive activities in the early stage of withdrawal This study reveals the dynamic change of time perception of ice addicts after abstinence, which is expected to be an important cognitive index of brain function change of drug addicts and a potential evaluation index of rehabilitation intervention.