Lung pleuripotent stem cells can be "cross-border" to participate in lung regeneration

lungs are the body's respiratory organs and are essential for gas exchange and resistance to pathogen invasion. Once the lungs are damaged, normal human life activities will also be affected. A new study by Zhou Bin, of the Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences, confirms that there is a lung pleuripotent stem cell in the human body that is involved in lung regeneration, which can be "differentiated on demand" to complete "cross-border repair" inside the lungs. The results were published February 19 in the international academic journal Nature Genetics.Previous studies have shown that when lung tissue is damaged, multiple lung bronchia endocellum cells and albathic endocells multiply and differentiate in large numbers, replacing damaged dead cells to maintain the normal function of pulmonary respiratory function. They are powerful, but only "specialized" in one area: the endocysts in different locations are only responsible for maintaining and repairing the endocys of their respective regions.In recent years, scientists have proposed a new type of pulmonary porocyte stem cell, the bronchid alba stem cell (BASCs), located at the junction of the small bronchid and the alba bubble, with molecular characteristics of the bronchid cortical rod cells and type II albathic cortical cells. But whether these cells are real in the body and have the potential to differentiate has been debated.Zhou Bin research team used a new dual-lying recombinant marker technology to achieve specific markers and tracer BASCs in laboratory mice, proving that BASCs do exist at the same time, and found that under normal conditions, BASCs can achieve slow self-renewal and maintain lung function. The researchers also found through a series of experiments that BASCs have the potential for "cross-border" multi-way differentiation in different damage models. When drugs are used to damage the pulmonary bronchii, BASCs can multiply and differentiate into bronchosive cortical rod cells and fibre cells, and when drugs are used to damage the alves, these BASCs can multiply and differentiate into type I and type II albathic cells, which in turn restore lung function.this research provides a new way of thinking for lung injury repair and regenerative medicine research, and provides a solid theoretical basis for stem cell therapy for lung disease. (Science and Technology Daily)