Lose weight and it's up to you! Nature has found that eosinophils activate beige fat to burn energy!

, June 20, 2020 /PRNewswire-BIOON/ -- An immune cell called eosinophils, a recent study published in Nature Communications, suggests that an immune cell called eosinophils may be an important part of the process of activating "rice fat."If future studies confirm this hypothesis, these cells could be targeted for future anti-obesity treatmentsthere are three types of fat or adipose tissue in thebody"Simply put, white fat -- the fat we usually think of -- stores excess energy," said DrKate Quinlan, lead author of the studyBrown fat, on the other hand, burns energy and generates heat in a process called heatThis phenomenon is particularly important in infants and hibernating animals, and recent studies have shown that it also exists in adults"Beige fat is a newly discovered energy-burning fat that can appear in white adipose tissue to produce heat rather than store energy."photo source: In this paper, the team studied a model of a mutated mouse that fights obesityThey found that it increased the activity of beige fats"We wonder why," DrQuinlan said"We also noticed that the mutated mice had more immune cells called eosic granulocytes, and we wondered if that was the answer."in a key experiment, the authors transplanted immune cells from mutant mice into normal miceWhen the mice were given a high-fat, high-sugar "Western" diet, the mice were eventually free from obesityThis suggests that immune cells, known to exist in fat and signal to fat, are involved in the process of discoloring and fighting obesity in mutated mice"While many different immune cells may be important, we are working on the hypothesis that metabolic regulation involves eosinophils," said DrQuinlan"
eosinophils are a rare type of immune cell that is important in the immune response to parasitic infections and has a negative effect onasthma, Crohn's disease and ulcerative colitis, but are considered beneficial for fat production"In lean beige fat mice, there are more eosinophils in the adipose tissue, which have a unique gene expression spectrum," said DrQuinlanWe also found evidence that eosinophils secrete signaling molecules that play a role in the activation of beige fat, providing a possible link between these mysterious immune cells and their beneficial functionin in adipose tissue"
obesity is a worldwide health epidemicIn 2016, more than 1.9 billion adults were overweight and more than 650 million were classified as obese"This is a serious problem because obesity increases the risk of chronic diseases such asdiabetesand heart disease," dr Quinlan said Dr Quinlan said: "Converting the white fat that stores energy into energy-burning beige fat is an attractive obesity treatment strategy, but the mechanism that drives the process in the body is not yet clear While more research is needed to further validate our hypothesis, this study suggests that eosinophils may play a larger role in activating beige fats than previously thought "
Dr Quinlan and her team are now focusing on finding new factors in the secretion of eosinophils that stimulate the activation of beige fats These factors may form the basis for future treatments to activate beige fat and try to reverse obesity (BioValleyBioon.com) References: Knights, A.J., Vohralik, E.J., Houweling, P.J et al.
Eosinophil function in adipose tissue is regulated by Kr?ppel-like factor 3 (KLF3) Nat Commun 11, 2922 (2020) https://doi.org/10.1038/s41467-020-16758-9