Long-term use of metformin in high-risk diabetic patients is not related to cognitive decline

According to a US study, long-term use of metformin in patients at high risk of diabetes was not associated with cognitive decline This finding adds confidence for clinicians and patients to use metformin for diabetes prevention Previous studies have shown that metformin use may be related to the deterioration of cognitive function and even the development of Alzheimer's disease, while other studies have shown that it can even improve memory According to the analysis of diabetes prevention outcomes in more than 2000 adults (http:// published online on May 12 in diabetes care, the use of metformin for more than 8 years will not lead to cognitive impairment The diabetes prevention study (DPP) was a placebo-controlled trial (http:// involving 3234 prediabetes individuals The study found that the incidence rate of type 2 diabetes decreased by 58% and 31% respectively in the intensive lifestyle intervention group and metformin group compared with placebo group After a 13-month transition period, participants continued to dppos The current situation analysis mainly focused on 2280 participants, including 749 in the lifestyle intervention group, 776 in the metformin group and 755 in the placebo group All participants completed the cognitive function assessment in the eighth year At the time of randomization, the average age of participants was 51.1 years old, 67.7% female and 54.6% white In the 8-year evaluation, the fasting blood glucose level, HbA1c area under the curve, and the prevalence and duration of type 2 diabetes in metformin and lifestyle intervention group were lower than those in placebo group In addition, there was no significant difference in the cognitive function of the three groups in the eighth year: lifestyle intervention group composite z-0.01, metformin group composite z-0.02, placebo group composite z-0.01 (P = 0.86) The results were independent of age and ApoE - ε 4 carrier status, which was considered a risk factor for cognitive impairment After adjusting for age, gender and race, the researchers also found no correlation between metformin exposure time and cognitive performance The researchers stressed that research on brain imaging changes will be carried out to further explore the correlation between metformin and brain changes.