Locally advanced head and neck cancer is also curable!

Compared with tumors in other parts, although the incidence of head and neck cancer is not high, due to the complex anatomy, dense organs, and many types of diseases, especially for locally advanced head and neck cancer, a single treatment method cannot meet the needs of head and neck cance.

Minimally invasive surgery

Compared with tumors in other parts, the treatment of head and neck cancer needs to take into account the preservation of function and appearance while curing the diseas.

A study published in 2020 analyzed and evaluated treatment strategies and outcomes for locally advanced head and neck squamous cell carcinom.

▲ Source: reference source [1]

On the other hand, with the continuous development of surgical techniques, the emergence of transoral surgery (TOS) provides new treatment options for head and neck cancer patient.

A study published in 2022 (ECOG 3311) evaluated the effect of transoral surgery (TOS) combined with postoperative adjuvant therapy for locally advanced oral cance.

▲ Source: reference source [2]

On the other hand, the emergence of the da Vinci robotic surgery system also provides new options for the treatment of patients with head and neck cance.

Proton therapy

As an emerging radiotherapy technology, proton therapy can deposit a large portion of the radiation dose in a highly concentrated area, thereby reducing radiation exposure to adjacent organs at risk and normal tissues, reducing treatment-related toxicity and improving patient lif.

The study, published June 25, 2021, in the International Journal of Particle Therapy analyzed the results of a 12-year survey of proton therapy for head and neck cance.

▲ Source: reference source [3]

Immunotherapy combined with chemoradiotherapy

Results of a 2022 American Society of Clinical Oncology (ASCO) study investigating the efficacy of concurrent or sequential pembrolizumab in addition to chemoradiotherapy (CRT) in treatment-naïve patients with locally advanced head and neck cancer will be presented orally The form was released, providing new ideas for the treatment of locally advanced head and neck cance.

The study was honored in patients with intermediate-risk HPV-positive locally advanced head and neck squamous cell carcinoma and HPV-negative patients with locally advanced head and neck squamous cell carcinoma of the oropharyngeal/hypopharyngeal/larynx/oral cavit.

The results of the study showed that the effects of both the concurrent treatment group and the sequential treatment group were very significan.

▲ Source: reference source [4]

Photoimmunotherapy

In September 2020, the Japanese Ministry of Health, Labour and Welfare approved the world's first photoimmunotherapy drug, Akalux, for locally advanced head and neck cancers that cannot be surgically remove.

Reference source:

[1]Treatment strategy and outcomes in locally advanced head and neck squamous cell carcinoma: a nationwide retrospective cohort study (KCSG HN13–01) | BMC Cancer | Full Text

https://bmccance.

[2]Ferris RL, Flamand Y, Weinstein GS, Li S, Quon H, Mehra R, Garcia JJ, Chung CH, Gillison ML, Duvvuri U, O'Malley BW Jr, Ozer E, Thomas GR, Koch WM, Gross ND , Bell RB, Saba NF, Lango M, Méndez E, Burtness .

[3] Gunn GB, Garden AS, Ye R, Ausat N, Dahlstrom KR, Morrison WH, Fuller CD, Phan J, Reddy JP, Shah SJ, Mayo LL, Chun SG, Chronowski GM, Moreno AC, Myers JN, Hanna EY , Esmaeli B, Gilison ML, Ferrarotto R, Hutcheson KA, Chambers MS, Ginsberg LE, El-Naggar AK, Rosenthal DI, Zhu XR, Frank S.

[4]Protocol specified final results of the KEYNOTE048 Trial of Pembrolizumab as first line therapy for tecurrent/metastatic Head and Neck Squamous Cell Carcinoma,ASCO 201Abs 600

[5] Clump DA, et a.

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