Liver Int: Gallstones Increase The Risk of Liver and Pancreatic Cancer! Kailua research nearly 80,000 people

Gallstones are common, and a recent study of nearly 80,000 people showed that gallstones increase the risk of gastrointestinal cancerstudies showed that screening detected gallstones increased the risk of liver cancer by 128 percent, and in non-diabetic people, gallstones increased the risk of pancreatic cancer by 116 percentstudy also found that in the uncorrected model, gallbladder excision also increased the risk of small bowel cancer by 19.2%, although due to the small number of cases, no multi-factor analysiswhy gallstones increase the risk of gastrointestinal cancer?gallstones can lead to the accumulation of bile acid, and bile acid disorders, will slowly induce liver cell metabolism conversion, increase liver oxidative stress levels, leading to DNA damage, mitochondrial damage and damage to liver cell membranes, in addition to the loss of bile acid receptor anti-inflammatory effects, which promote the occurrence of liver cancerin addition, gallstones can lead to chronic inflammation of the gallbladder and often secondary intestinal infections, ultimately increasing the risk of cancerAfter gallbladder removal, it may cause persistent bile to enter the intestines, altering metabolic hormone levels, increasing the risk of gastrointestinal cancerHow canprevent gallstones?many studies confirm edgy high-risk factors, including diet and lifestyle is very important, a large number of studies, high fat, high sugar, high protein, low fiber diet will increase the incidence of gallstones, weight loss is importantStudies have shown that the more severe obesity, the higher the incidence of gallstoneA history of biliary tract infections, smoking, drinking, etccan also increase the risk of stone exposureKailusion study this analysis included in 2006 79,809 men who underwent gallbladder ultrasound, participated in the study without gastrointestinal cancer, 2005 people detected gallstones, of which 1857 people had gallstones, 148 people received gallbladder excision1,264 people developed gastrointestinal cancer, including 303 cases of liver cancer and 94 cases of pancreatic cancer, over an average follow-up period of 11 years