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Liver Cnacer: Real-world evaluation of the efficacy of Lenvatinib in the treatment of unresectable hepatocellular carcinoma (HCC)

 Last Update: 2021-10-10
 Source: Internet
 Author: User

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Lenvatinib was recently approved as a first-line treatment for patients with unresectable hepatocellular carcinoma (HCC)

The study included 111 patients for efficacy analysis

The median follow-up time was 6.

Efficacy evaluation

When evaluating whether to meet the REFLECT eligibility criteria, there was no difference in ORR between the eligible and non-compliant cohorts (20.

When evaluated based on whether the REFLECT eligibility criteria were met, the median OS of the eligible cohort was significantly longer than that of the non-compliant cohort (13.

Evaluation according to REFLECT standard

AEs occurred in 86/116 patients (74.

In summary, real-world data show that Lenvatinib has good efficacy and safety in the treatment of advanced hepatocellular carcinoma (HCC)

Original source:

Goh MJ, Oh JH, Park Y, Kim J, Kang W, Sinn DH, Gwak GY, Paik YH, Choi MS, Lee JH, Koh KC, Paik SW.

Goh MJ, Oh JH, Park Y, Kim J, Kang W, Sinn DH, Gwak GY, Paik YH, Choi MS, Lee JH, Koh KC, Paik SW.
Efficacy and Safety of Lenvatinib Therapy for Unresectable Hepatocellular Carcinoma in a Real- World Practice in Korea.
Liver Cancer.
2021 Feb;10(1):52-62.
doi: 10.
1159/000512239.
Epub 2021 Jan 8.
PMID: 33708639; PMCID: PMC7923940.

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