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Liver Cancer: Pembrolizumab (Pembrolizumab) second-line application in advanced liver cancer efficacy: subgroup analysis results from KEYNOTE-240 Asian population

 Last Update: 2021-05-20
 Source: Internet
 Author: User

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KEYNOTE-240 is a double-blind, placebo-controlled, randomized phase 3 study.

This study mainly analyzed the effectiveness and safety of pembrolizumab in Asian population.

Median PFS: 2.

PFS

Median OS: 13.

ORR: Pembrolizumab group compared to control group was 20.

Clinical benefit rate

Treatment-related adverse events of any grade: 58.

Treatment-related adverse events

In summary, pembrolizumab is effective in the second-line treatment of advanced liver cancer in Asian population and the toxicity is tolerable.

In summary, pembrolizumab is effective in the second-line treatment of advanced liver cancer in Asian populations and the toxicity is tolerable.

Original source:

Masatoshi Kudo, Ho Yeong Lim, Ann-Lii Cheng, et al.

Masatoshi Kudo, Ho Yeong Lim, Ann-Lii Cheng, et al.
Pembrolizumab as Second-Line Therapy for Advanced Hepatocellular Carcinoma:A Subgroup Analysis of Asian Patients in the Phase 3 KEYNOTE-240 Trial.
Liver Cancer.
2021.
https:// doi.
org/10.
1159/000515553.
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