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Liu Junli's team at the Sixth People's Hospital of the Affiliated Sixth People's Hospital discovered a new mechanism for promoting cancer-promoting browning of perrenal fat

 Last Update: 2021-10-01
 Source: Internet
 Author: User

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On September 10th, Liu Junli's research group from the Sixth People's Hospital affiliated to Shanghai Jiaotong University and Wang Linhui's research group from the Department of Urology, Shanghai Changhai Hospital published an online publication titled "The thermogenic activity of adjacent adipocytes fuels the progression" in the internationally renowned academic journal "Cell Metabolism" of ccRCC and compromises anti-tumor therapeutic efficacy" research paper
.

The author revealed that there is a "bi-directional communication" pattern between renal clear cell carcinoma and adjacent peripheral fat
.

ccRCC can promote the browning of perirenal fat, and the browned perirenal fat can promote the growth, invasion and metastasis of ccRCC tumors by secreting excessive lactic acid

The author consulted the clinical practice guidelines of China and the United States, and found that there is still no clear guidance on whether ccRCC patients should remove the adjacent adipose tissue during partial nephrectomy
.

The author's research results show that ccRCC induces browning of adjacent perirenal fat, which promotes tumor growth, invasion and metastasis by secreting lactic acid

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