Literature analysis of systemic anaphylaxis caused by injection of gugua extract in 40 cases

Recently, Wang Zong of Gucheng County People's Hospital in Hubei Province published a paper to analyze the literature of 40 cases of allergic reaction caused by injection of bone melon extract, to explore the mechanism and characteristics of allergic reaction, and to provide reference for clinical safety and rational use of drugs The study points out that clinicians and pharmacists should pay attention to the occurrence of allergic reactions caused by injection of bone melon extract, understand its rules and characteristics, strengthen clinical detection, so as to reduce the occurrence of adverse reactions The article was published in China pharmacovigilance in November 2013 Based on the literature retrieval of the full-text database of Chinese journals from 1994 to 2013, 40 cases of allergic reactions of bone melon extract injection were analyzed The anaphylaxis of gugua extract injection was more in male than in female, and the incidence of anaphylaxis was higher in the high age group The anaphylaxis occurred in the process of medication, the shortest time was 30s after medication, the longest time was 10d after continuous medication, and most of them occurred within 30min after medication The main clinical manifestations of anaphylaxis involved multiple systems and organs, and the clinical manifestations were complex and varied There are skin and accessory damage, respiratory system, nervous system, cardiovascular system, digestive system, systemic damage and oral system, of which cardiovascular system is the main one; all cases were found in time, and drug was stopped immediately for symptomatic treatment, treatment and prognosis were good, no death cases were reported.