Lin Aifu's research group of the Chinese Academy of Biological Sciences published a paper in Nature Metabolism to reveal RNA-mediated organelles...

As an important carrier of material and energy metabolism, organelles have unique biological function molecules that are orderly regulated, supporting the efficient implementation of various biochemical reactions

As an important lipid molecular element, cholesterol is involved in many important physiological and biochemical processes of the

At present, it is known that more than 90% of human nucleic acid transcripts are non-coding RNAs, and long-chain non-coding RNAs (LncRNAs) play an important regulatory role

On August 22, 2022, Lin Aifu's research group at the School of Life Sciences of Zhejiang University published a research paper

Based on the mapping and exploration of LncRNA in the early organelles, the study found that LncRNA SNHG6 (small nucleolar RNA host gene 6) specifically responds to cholesterol and is distributed in the interaction area of lysosomal and endoplasmic reticulum, promoting malignant proliferation and poor prognosis

Figure 1 Cholesterol regulates SNHG6-FAF2-mTOR signaling complex assembly in the organelle interaction region

Further, the authors used a cholesterol-induced naflD-HCC mouse model to confirm the regulatory role of SNHG6 in the dynamic evolution of tumors, and found that overexpression of SNHG6 in mouse livers will promote the activation of the cholesterol-induced mTORC1 signaling pathway and accelerate the malignant lesion process

Figure 2 Pattern of SNHG6 modulating cholesterol-dependent mTORC1 activation within the organelle interaction region

In summary, this study clarifies the relationship between LncRNA localization and function by in-depth and systematic analysis of the spatiotemporal dynamic metabolic regulation mechanism of the fine area of the intracellular endometrial system by in-depth and systematic analysis of the mechanism of LncRNA SNHG6 mediated, which will broaden the breadth and depth of the cognition of the dynamic behavior and function of organelles, and provide a new perspective and theoretical basis

Liu Fangzhou and Zhang Zhen, phD students of Zhejiang University Of Science and Technology, and Dr.

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