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Predatory predation is the instinctive behavior of animals, including a series of continuous actions such as looking for prey, pursuing, and attacking, which is vital to the survival of animals
.
Multiple brain regions such as the superior colliculus, amygdala, hypothalamus and periaqueductal gray matter (PAG) are involved in predation behavior
.
PAG participates in defensive behaviors, social behaviors, emotions and maternal behaviors, and can be subdivided anatomically into dorsal medial (DMPAG), dorsal lateral (DLPAG), lateral (LPAG) and ventral lateral (VLPAG)
.
Studies have shown that LPAG's ability to chase or attack prey is weakened after damage to the brain area
.
On November 10, 2021, the joint research team of Li Haohong of Zhejiang University and Shen Wei of Shanghai University of Science and Technology revealed that the LPAG neuron group encodes the sequential action information of predatory behavior.
This sequential pattern is strictly regulated by the upstream input signal
.
Researchers used in vivo electrophysiological technology to record the discharge characteristics of LPAG brain neurons in different stages of the mouse predation of crickets (prey invasion, chasing prey, biting and attacking prey, eating prey), and found that LPAG brain regions during the predation process Neurons are widely activated
.
More specifically, inhibitory neurons in the LPAG brain area are activated during invasion, chase, and attack, while excitatory neurons in this brain area are mainly activated during the attack process
.
After inhibiting the inhibitory neurons in the LPAG brain area by optogenetic technology, the number of chases in the chase phase is increased, and the latency of the attack is prolonged
.
However, after inhibiting excitatory neurons in this brain area, the time to successfully capture prey during the attack phase increases, and the capture efficiency decreases.
These results further confirm that the inhibitory neurons and excitatory neurons in the LPAG brain area perform different functions in the capture behavior
.
Subsequent experiments found that LPAG brain neurons fired more after visual stimulation of movement, but there was almost no change in auditory stimulation or static visual stimulation
.
Neurons in the LPAG brain area were also activated in the risk assessment experiment and the prey identification experiment
.
These results further indicate that the LPAG brain region neurons regulate the continuous process of predation behavior: sensory detection (seeing the prey), risk assessment (whether there is risk in chasing the prey) and target identification information (targeting)
.
Virus tracing experiments found that the inhibitory neurons in the LPAG brain area received from the lateral stiff nucleus, the indeterminate zone, and the central amygdala
.
After further using viral vector tools to specifically induce apoptosis of central amygdala neurons in the upstream brain area of LPAG, it mainly reduces neuronal activity in the chase and attack phases, and induces the death of lateral stiff nucleus neurons, which mainly affects the neuronal discharge activity in the attack phase , After inducing the death of neurons in the indefinite zone, it mainly affects the discharge activity of the prey invasion and chasing phase, and the movement ability of the mice is weakened
.
In summary, this article reveals that excitatory neurons and inhibitory neurons in the LPAG brain region regulate different stages of predation behavior.
In addition, the lateral stiff nucleus→LPAG, indeterminate zone→LPAG, and central amygdala→LPAG are also strictly regulated.
Different stages of predation behavior
.
[References] https://doi.
org/10.
1038/s41467-021-26852-1 The pictures in the article are from the references
Predatory predation is the instinctive behavior of animals, including a series of continuous actions such as looking for prey, pursuing, and attacking, which is vital to the survival of animals
.
Multiple brain regions such as the superior colliculus, amygdala, hypothalamus and periaqueductal gray matter (PAG) are involved in predation behavior
.
PAG participates in defensive behaviors, social behaviors, emotions and maternal behaviors, and can be subdivided anatomically into dorsal medial (DMPAG), dorsal lateral (DLPAG), lateral (LPAG) and ventral lateral (VLPAG)
.
Studies have shown that LPAG's ability to chase or attack prey is weakened after damage to the brain area
.
On November 10, 2021, the joint research team of Li Haohong of Zhejiang University and Shen Wei of Shanghai University of Science and Technology revealed that the LPAG neuron group encodes the sequential action information of predatory behavior.
This sequential pattern is strictly regulated by the upstream input signal
.
Researchers used in vivo electrophysiological technology to record the discharge characteristics of LPAG brain neurons in different stages of the mouse predation of crickets (prey invasion, chasing prey, biting and attacking prey, eating prey), and found that LPAG brain regions during the predation process Neurons are widely activated
.
More specifically, inhibitory neurons in the LPAG brain area are activated during invasion, chase, and attack, while excitatory neurons in this brain area are mainly activated during the attack process
.
After inhibiting the inhibitory neurons in the LPAG brain area by optogenetic technology, the number of chases in the chase phase is increased, and the latency of the attack is prolonged
.
However, after inhibiting excitatory neurons in this brain area, the time to successfully capture prey during the attack phase increases, and the capture efficiency decreases.
These results further confirm that the inhibitory neurons and excitatory neurons in the LPAG brain area perform different functions in the capture behavior
.
Subsequent experiments found that LPAG brain neurons fired more after visual stimulation of movement, but there was almost no change in auditory stimulation or static visual stimulation
.
Neurons in the LPAG brain area were also activated in the risk assessment experiment and the prey identification experiment
.
These results further indicate that the LPAG brain region neurons regulate the continuous process of predation behavior: sensory detection (seeing the prey), risk assessment (whether there is risk in chasing the prey) and target identification information (targeting)
.
Virus tracing experiments found that the inhibitory neurons in the LPAG brain area received from the lateral stiff nucleus, the indeterminate zone, and the central amygdala
.
After further using viral vector tools to specifically induce apoptosis of central amygdala neurons in the upstream brain area of LPAG, it mainly reduces neuronal activity in the chase and attack phases, and induces the death of lateral stiff nucleus neurons, which mainly affects the neuronal discharge activity in the attack phase , After inducing the death of neurons in the indefinite zone, it mainly affects the discharge activity of the prey invasion and chasing phase, and the movement ability of the mice is weakened
.
In summary, this article reveals that excitatory neurons and inhibitory neurons in the LPAG brain region regulate different stages of predation behavior.
In addition, the lateral stiff nucleus→LPAG, indeterminate zone→LPAG, and central amygdala→LPAG are also strictly regulated.
Different stages of predation behavior
.
[References] https://doi.
org/10.
1038/s41467-021-26852-1 The pictures in the article are from the references
