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Leukemia: Efficacy and Safety of Guadecitabine in Patients with Peripheral T-Cell Lymphoma

 Last Update: 2022-05-22
 Source: Internet
 Author: User

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Peripheral T-cell lymphoma (PTCL) is a rare, heterogeneous malignancy with an extremely poor prognosis when it relapses

Guadecitabine, a decitabine analog, has shown good efficacy in MDS patients

This study is a single-center Phase II clinical trial recruiting patients 18 years of age and older with an ECOG performance status of ≤3, histologically diagnosed, treatment-naïve, or relapsed/refractory PTCL, treated with Treatment with citabine (60 mg/m2) on days 1-5/28 until disease progression

The overall response rate was 40%, including 10% complete response The overall response rate was 40%, including 10% complete response

RHOAG17V mutation is associated with prolonged progression-free survival

In conclusion, Guadecitabine demonstrated acceptable overall response rates and toxicity profiles in patients with peripheral T-cell lymphoma ; decitabine analogs may be promising candidates for future combined targeting of histone methyltransferases.

Guadecitabine demonstrated acceptable overall response rate and toxicity profile in patients with peripheral T-cell lymphoma Guadecitabine demonstrated acceptable overall response rate and toxicity profile in patients with peripheral T-cell lymphoma Overall response rate and toxicity profile

Original source:

Original Source: Original Source:

Wong Jonathan, Gruber Emily, Maher Belinda et al.

Wong Jonathan, Gruber Emily, Maher Belinda et al.
Integrated clinical and genomic evaluation of guadecitabine (SGI-110) in peripheral T-cell lymphoma.
[J] .
Leukemia, 2022, https://doi.
org/10.
1038/s41375- 022-01571-8

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