Leptin induced proliferation of hepatic stellate cells and regulation of Ginkgo biloba extract
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Last Update: 2014-03-04
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Source: Internet
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Author: User
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Recently, researchers from Zhejiang Academy of traditional Chinese Medicine published a paper to observe the effect of Ginkgo biloba extract (GBE) on the proliferation of HSC induced by exogenous leptin It is suggested that leptin can stimulate the proliferation of HSC, and GBE can inhibit the activation pathway of HSC stimulated by leptin, which may be an important mechanism of anti fibrosis This article was published in the 11th issue of Zhejiang Journal of integrated traditional and Western medicine in 2013 HSC-T6 cells were stimulated by different concentrations of leptin (0, 10, 50, 100, 200, 400 μ g / L) at different time phases (6, 12, 18, 24 hours), and HSC-T6 cells stimulated by Ginkgo biloba extract (20, 40, 80, 160 mg / L) at the same time Cell proliferation Different doses of leptin showed dose-dependent and time-dependent effects on HSC-T6 cell proliferation at different time points (P < 0.05) Ginkgo biloba extract could significantly inhibit the proliferation of HSC-T6 stimulated by leptin (P < 0.05).
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