Lentinan is widely used in tumor immunotherapy

Lentinan is a kind of biological polysaccharide extracted from the fruiting body of Lentinus edodes, which has many pharmacological effects It is a kind of natural immunomodulator, which has no killing effect on tumor cells However, by activating T lymphocytes, it can enhance the killing power of NK and LAK cells, enhance the activity of cellular immune system, increase the secretion of various lymphocyte factors, activate megaphagocytes, secrete a large number of cytotoxic substances, and enhance the phagocytic ability At the same time, the red cell immune system When activated, the immune system works together to inhibit tumor cell proliferation and destroy tumor cells Lentinan, as an important biological regulator, has been widely used in the immunotherapy of tumor In clinic, lentinan combined with radiotherapy and chemotherapy is often used to treat malignant tumor Some studies have used chemotherapy drugs 5-fluorouracil, adriamycin and mitomycin to treat patients with advanced or postoperative recurrence of gastric cancer Lentinan was dripped 4 days before chemotherapy After 8 weeks of treatment, the total remission rate was 62.7%, significantly higher than 38.9% The total effective rate of chemotherapy MVP combined with lentinan for 8 weeks was 53.6%, while that of chemotherapy alone was 41.7% In some studies, lentinan combined with chemotherapy chop was used to treat non Hodgkin's lymphoma Three days before chemotherapy, lentinan was infused intravenously After six weeks of chemotherapy with chop, the total effective rate of the patients reached 87.5%, significantly higher than 67.9% of chemotherapy with chop alone In the clinical treatment of cardiac cancer, breast cancer, lymphoma, small cell lung cancer, liver cancer, gastrointestinal cancer and other advanced cancer, lentinan combined with chemotherapy can significantly improve the total effective rate compared with chemotherapy alone The results showed that the T cell subsets CD3 +, CD4 + cells decreased, CD8 + cells increased, CD4 / CD8 ratio imbalance, NK cells, LAK cells activity decreased in varying degrees, which led to the decline of anti-tumor immune function The results showed that NK cell activity and lymphocyte transformation rate increased significantly after lentinan combined with chemotherapy, and T lymphocyte, CD3 +, CD4 + and CD4 / CD8 increased to a certain extent It is proved that chemotherapy combined with lentinan can indirectly kill tumor cells, inhibit the rapid proliferation and distant metastasis of cancer cells after chemotherapy, and protect the immune function of host cells Chemotherapy combined with lentinan is effective in the treatment of advanced cancer, and in the clinical study, there is no significant difference between the adverse reactions of patients and chemotherapy alone Nanjing Yiheng Pharmaceutical Co., Ltd is an early manufacturer of lentinan preparation in China Its lentinan for injection (Yineng) has been widely used as an effective anti-tumor drug in clinical practice, with the characteristics of small side effects and reliable efficacy Especially for the immune function after the disease is inhibited by tumor, chemotherapy or the body quality is better than that of China Pharmaceutical Journal In poor patients, lentinan can enhance immunity, inhibit the development of tumor and improve the quality of life of patients In the aspect of anti-tumor treatment, lentinan has the value of further promotion and use.