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| Latest research: Chimeric embryos can also successfully give birth to test-tube babies |
One limiting factor for the success of in vitro fertilization (IVF) is the number of viable embryos that can be implanted in the uterus
.
On November 19, a study published in the American Journal of Human Genetics showed that many embryos discarded or downgraded due to chromosomal abnormalities may lead to a successful pregnancy
"We believe that these clinical data will solve some of the major problems in preimplantation genetic testing, and further help many infertile patients make more informed fertility decisions
.
" Scientific expert Antonio Capalbo said, “This trial may promote changes in IVF clinical management and support relevant departments to update guidelines and recommendations
Researchers studied the prevalence and distribution of aneuploid cells (cells with unbalanced chromosomes) in blastocysts (embryo precursors) made in the laboratory
.
They particularly observed a condition called chimerism, where both normal and aneuploid cells are present in the embryo
This time, the researchers conducted a double-blind trial.
They selected patients who received IVF from 5 hospitals in Italy.
Before implantation, the researchers conducted genetic tests on the embryos
.
In addition to euploid embryos, implanted embryos also include low chimerism (20% to 30% aneuploid cells) and medium chimerism (30% to 50% aneuploid cells)
"It is known that chimeric embryos may develop to term and produce healthy babies
.
However, many previous studies have been affected by selection biases, which tend to have a poor prognosis.
The researchers say that the current study avoids this prejudice through non-selective trials
.
In this test, any embryo that meets the criteria is eligible for transplantation
Capalbo said, “Our results show that the current mosaicism research does not provide any clinically useful information for IVF recipients
.
Therefore, it seems reasonable not to report relevant results after pre-implantation genetic testing.
The researchers hope that this study will immediately affect clinical practice, prompt relevant departments to update guidelines and recommendations, and allow patients undergoing IVF to improve the decision-making process when evaluating chimeric embryo transfer
.
(Source: Feng Lifei, China Science News)
Related paper information: https://doi.
org/10.
1016/j.
ajhg.
2021.
11.
002
org/10.
1016/j.
ajhg.
2021.
11.
002 https://doi.
org/10.
1016/j.
ajhg.
2021.
11.
002
