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| Lasker Prize winner Alberts talks about translational medicine: Scientists use first-year vocabulary to translate Shakespeare |
“I didn’t realize that biology has such a powerful complexity at the beginning
.
” At the World’s Leading Scientists’ Life Science 3.
Dean of the Academy of Sciences
Alberts is a world-renowned biochemist.
The textbook "Molecular Biology of the Cell" written by him and several other scientists is widely used in university introductory courses.
The book was first published in 1983 and was hailed as "the most contemporary The influential textbook of cell biology"
.
"This textbook I wrote has a history of 43 years, forcing me to read and discuss issues with experts.
Alberts emphasized that to understand the complexity of biology requires multidisciplinary cooperation
.
Starting from what he learned when he was young, he cited a diagram as an example, “We have been learning the so-called feedback and feedforward loops, from A to D, from D to E, but in fact, it’s not that simple.
He believes that the progress of textbooks in this area is very slow, and reminded that what the textbook writers have not realized is that all the positive and negative feedback loops based on cytochemistry create such a complex network of interactions.
These networks produce Important new features need new calculation methods to solve
.
Alberts said that we need more research to further promote related work, and we also need quantitative methods to analyze and understand the complexity of life chemistry
.
He also mentioned a status quo, "We know that the National Institutes of Health (NIH) often emphasizes so-called'translational' biomedical research, but in the face of so many unknowns, we believe that basic scientific research still has an understanding of biological mechanisms.
Alberts is also the former editor-in-chief of the top academic journal, the American "Science" magazine
.
He mentioned at the forum that he had reviewed more than 200 "Science" editorials, one of which was from a young female scholar—Huda Y Zoghbi), this article is well recognized by Alberts himself
The aforementioned editorial was published in 2013 and is entitled "The Basics of Translation.
" Zogby compared the task of translational research to the translation of a book from one language to another
.
Alberts directly quoted the original words of the article on the forum, "The challenge of translational medicine is that scientists are trying to use the vocabulary and experience of first-year students to translate texts as complex and deep as Shakespeare
Zogby emphasized at the time that our understanding of most pathway functions under different cell types, different developmental stages and normal physiological conditions is still preliminary and fragmentary
