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Lancet Oncology: Atezolizumab's global phase 3 clinical trial showed poor efficacy for advanced bladder cancer

 Last Update: 2021-05-20
 Source: Internet
 Author: User

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Muscle-invasive urothelial carcinoma (MIUC) is the most common type of bladder cancer.

The current standard of treatment for MIUC patients is a combination of surgery and cisplatin-based neoadjuvant chemotherapy.

In terms of safety assessment, the most common grade 3 or 4 adverse event was urinary tract infection (31 out of 390 patients in the experimental group (8%) vs.

infection

In addition, 122 (31%) patients receiving atezolizumab and 71 (18%) patients receiving observation experienced serious adverse events.

The overall study results indicate that atezolizumab is generally tolerable with no new safety signals; compared with studies on metastatic urothelial cancer, the frequency of adverse events leading to discontinuation is higher.

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