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Lancet Oncol: The correlation between various antihypertensive drugs and cancer risk

 Last Update: 2021-04-17
 Source: Internet
 Author: User

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Some studies have shown that there is a link between antihypertensive drugs and cancer, but so far it has not been completely determined .

Some studies have shown that there is a link between antihypertensive drugs and cancer, but so far it is still not completely certain

Researchers searched PubMed, MEDLINE, Cochrane Central Register of Control Trials, and ClinicalTrials.

Blood vessel

After screening, 33 trials finally met the inclusion criteria, including 260,447 subjects and 15012 cancer events .

Included 260,447 subjects and 15012 cancer incidents

Correlation of various antihypertensive drugs with any cancer risk

In a meta-analysis of individual subject data comparing each drug category with all other control drugs, no antihypertensive drugs were found to be associated with any cancer risk, except for calcium channel blockers (1.

In a network meta-analysis comparing drug categories with placebo, the researchers still did not find that any drug category would increase the risk of additional cancer (ACEI: HR 1.

In summary, the study did not find consistent evidence that the use of antihypertensive drugs has any effect on cancer risk .

The study did not find consistent evidence that the use of antihypertensive drugs had any effect on cancer risk The study did not find consistent evidence that the use of antihypertensive drugs had any effect on cancer risk

Original source:

Copland Emma,Canoy Dexter,Nazarzadeh Milad et al.

org/10.
1016/S1470-2045(21)00033-4" target="_blank" rel="noopener">Antihypertensive treatment and risk of cancer: an individual participant data meta-analysis

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