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    Home > Active Ingredient News > Antitumor Therapy > Lancet Oncol: Radiotherapy can delay the systemic treatment time of oligometastatic renal cell carcinoma

    Lancet Oncol: Radiotherapy can delay the systemic treatment time of oligometastatic renal cell carcinoma

    • Last Update: 2021-11-12
    • Source: Internet
    • Author: User
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    Renal cell carcinoma is a kind of clinically heterogeneous malignant tumors, which often metastasize widely and progress rapidly
    .


    Patients with oligometastasis usually have a blunt clinical course


    This is a single-arm, phase 2 feasibility trial that recruits renal cell carcinoma patients who are 18 years of age or older, with no more than 5 metastatic lesions, ECOG performance status 0-2, and previous systemic treatment ≤1 times
    .


    The patient received whole body stereotactic radiotherapy (defined as ≤5 times, each time ≥7 Gy) to treat all the lesions, and the systemic treatment was suspended


    Progression-free survival

    From July 13, 2018 to September 18, 2020, a total of 30 patients (6 [20%] women) were recruited
    .


    All patients had clear cell carcinoma and had undergone nephrectomy before enrollment


    The patients were followed up for 17.


    Survival without system treatment

    In summary, sequential radiotherapy may help delay the start of systemic treatment and may allow patients with specific oligometastatic renal cell carcinoma to continue to interrupt systemic treatment


    Sequential radiotherapy may help delay the start of systemic treatment and may allow patients with specific oligometastatic renal cell carcinoma to continue to interrupt systemic treatment.


    Original source:

    Chad Tang, et al.


    Definitive radiotherapy in lieu of systemic therapy for oligometastatic renal cell carcinoma: a single-arm, single-centre, feasibility, phase 2 trial in this message
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