Lancet Oncol: Increased risk of death from new coronary pneumonia in patients with chest tumours

Studies have shown that patients withCOVID-19with tumors have a high mortality rate, and researchers recently examined the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)infectionon patients with breast cancerTERAVOLT study, COVID-19 patients with any chest tumor (non-small cell lung cancer (NSCLC), small cell lung cancer, mesothelioma, thymus epithelioma, and other pulmonary neuroendocrine tumors) participated in the collection of data on demographics, tumor history and co-disease, COVID-19diagnosis, course and clinical outcomesUsing the single-variable and multivariate Logistic regression method, the relationship between demographic or clinical characteristics and prognosis was examined, and gender, age, smoking status, hypertension and chronic obstructive pulmonary disease were included in the multivariate analysis200 patients with COVID-19 infection with chest cancer from 8 countries with a median age of 68.0 years, with an ECOG score of 0-1 (142/196, 72%), most of whom were current or former smokers (159/196) 81%), the majority of non-small cell lung cancer (151/200, 76%), most were being treated at the time of COVID-19 diagnosis (147/199, 74%), and 112 (57%) of 197 cases received first-line treatment152 (76%) patients were hospitalized and 66 (33%) diedOf the 134 patients who met the ICU admission criteria, 13 (10%) entered the ICU and the remaining 121 were hospitalized but not in the ICUSingle-variable analysis showed that age over 65 (OR:1.88), smoking or previous smoking (4.24), chemotherapy (2.54) and any co-disease (2.65) were associated with an increased risk of deathIn the multivariate analysis, only smoking history (OR:3.18) was associated with an increased risk of deathstudy found that breast tumor patients infected withnew coronary pneumonia, the mortality rate is higher, the rate of intensive care admission is low, whether through intensive care treatment to reduce the mortality rate is still to be determined