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Lancet Oncol: Duvalumab and Tremelimumab in Advanced Metastatic Sarcoma

 Last Update: 2022-08-19
 Source: Internet
 Author: User

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Patients with metastatic sarcoma have few standard treatment option.

This is a single-center, phase 2 trial that enrolled patients 18 years of age and older with at least one prior systemic therapy with advanced or metastatic sarcoma with an ECOG performance status of 0-1 who received intravenous duvalumab ( 1500 mg) and tremelimumab (75 mg) for 4 cycles, followed by maintenance duvalumab (1 time/4 weeks) for 12 month.

Between August 17, 2016, and April 9, 2018, a total of 62 patients were enrolled, of whom 57 (92%) received study treatment and were included in the intent-to-treat populatio.

A total of 21 grade 3-4 treatment-related adverse reactions were reported, the most common being increased lipase (7%), colitis (5%), and pneumonitis (5%.

In conclusion, the combination regimen of durvalumab and tremelimumab is an effective treatment strategy for patients with advanced or metastatic sarcoma, and further relevant trials are worthy of evaluatio.

Original source:

Neeta Somaiah, et a.

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