Lancet oncol: Dallafinib co-cinnatonine treats bile duce cancer with BRAF V600E mutation.

There is currently no effective way to treat patients with bile tube cancer who are progressing after chemotherapy in Gixitham.
mutations in the BRAF gene were found in 5% of patients with bile gallblader tumors.
with D'Alafinib and Qumeitinib showed anti-tumor activity in several cancers with BRAF (V600E) mutations.
study aims to assess the efficacy and safety of a joint programme of dallafinib and qumeitinib for patients with bile duce cancer with BRAF (V600E) mutations.
the report is part of an ongoing Phase 2 single-arm multicenter trial in which patients with BRAF (V600E) mutations, which cannot be surgically removed, metastatic, locally advanced or relapsed bile duodenal cancer over the age of 18, have been systematically treated in the past.
all patients were treated oral with dallaffini (150 mg, 2/day) and qumeitini (2 mg, 1/day) until the disease progressed.
end point is the overall mitigation rate.
March 12, 2014 - July 18, 2018, 43 eligible patients were recruited.
follow-up for 10 months (IQR 6-15).
22 patients received the overall remission assessed by observers (51 per cent).
(47 per cent) was assessed by 20 independent examiners.
most common level 3 adverse reactions were elevated gamma-glutamine transferase (12%).
17 patients had severe adverse reactions and 9 had treatment-related severe adverse reactions, the most common of which was fever (8 cases).
treatment-related deaths.
of Lafinib and Qumeitinib demonstrates expected efficacy and safety in patients with bile tube cancer with BRAF (V600E) mutations.
it is worth considering routine BRAF (V600E) mutation detection in patients with bile tube cancer.
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