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Primary chemotherapy for breast cancer presents a dilemma with adjuvant local radiotherapy because guidelines for local radiotherapy were originally based on the pathological findings of primary surger.
This prospective registry study included patients referred to one of 17 radiation oncology centres in the Netherlands between January 1, 2011 and January 1, 2015, who received initial chemotherapy and breast-grade axillary surgery for cT1- Patients with stage 2N1 breast cance.
838 patients were eligible for the 5-year follow-up analysis: 291 in the low-risk group, 370 in the intermediate-risk group, and 177 in the high-risk grou.
In conclusion, the 5-year locoregional recurrence rate of all breast cancer patients in this study was less than 4%, supporting the researchers' hypothesis that in patients with cT1-2N1 stage breast cancer receiving primary chemotherapy, recurrence based on locoregional Risk-reducing locoregional radiation doses are oncologically saf.
Original source:
Sabine R de Wild, et a.