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Lancet Neurology: Safety and Efficacy of Tiranezumab in the Treatment of Progressive Supranuclear Palsy: A Phase 2 Randomized Placebo Controlled Trial

 Last Update: 2021-03-21
 Source: Internet
 Author: User

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Tau disease refers to the disorder of tau protein aggregation, which is heterogeneous in biochemistry, morphology and clinical manifestations.

This is a phase 2, multi-center, randomized, placebo-controlled, double-blind study conducted in 66 hospitals and clinics in multiple countries.

diagnosis

From December 12, 2016 to December 31, 2018, a total of 466 participants were screened and 378 participants were randomly divided into groups.

In this phase 2 study of progressive supranuclear palsy, although Telavirumab was not effective in the treatment of progressive supranuclear palsy, the safety of all treatment groups was similar.

Biomarker analysis showed that Tiranezumab binds to target cells.

Höglinger, Günter UAhmed, Anwar et al.
Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomised, placebo-controlled trial.
The Lancet Neurology, Volume 20, Issue 3, 182-192 Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomised, placebo-controlled trial.
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