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Lancet Neurol: Poor tolerability, negative efficacy-bexarotene is not recommended for the treatment of relapsing-remitting multiple sclerosis (CCMR ONE)

 Last Update: 2021-11-02
 Source: Internet
 Author: User

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The most effective strategy for preserving demyelinated axons is to promote endogenous remyelination

Another positive regulator of the differentiation of oligodendrocyte precursor cells is the retinoic acid X receptor (RXR) , which is expressed in remyelinating multiple sclerosis lesions in cells of the oligodendrocyte lineage

Randomized, double-blind, placebo-controlled, parallel grouped Phase 2a trial (CCMR One)

Between January 17, 2017 and May 17, 2019, 52 participants were randomly assigned to receive bexarotene (n=26) or placebo (n=26)

The study does not recommend the use of bexarotene to treat patients with multiple sclerosis because it is poorly tolerated and the main efficacy result is negative

SoSTART Collaboration.
Effects of oral anticoagulation for atrial fibrillation after spontaneous intracranial haemorrhage in the UK: a randomised, open-label, assessor-masked, pilot-phase, non-inferiority trial.
Lancet Neurol.
2021;20(10):842- 853.
doi:10.
1016/S1474-4422(21)00264-7

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