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Lancet Neurol: Diagnosis and prognostic performance and longitudinal changes of plasma neurofilament light chain concentration in adults with Down syndrome

 Last Update: 2021-11-02
 Source: Internet
 Author: User

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Recently, researchers have verified the clinical utility of plasma neurofilament light chain (NfL) in diagnosing Symptomatic Alzheimer’s disease with Down’s syndrome, assessing its prognostic value, and determining the longitudinal changes in adults with Down’s syndrome

Multicenter cohort study

Between August 2, 2010 and July 16, 2019, a total of 608 samples from 236 Down’s syndrome patients were analyzed: 165 (70%) were asymptomatic, and 32 (14%) had prodrome.

The plasma NfL concentration has excellent diagnostic and prognostic performance for symptomatic Alzheimer's disease in Down syndrome

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