Lancet Neurol: Closed-loop induced compound action potential stimulation used to improve chronic back and leg pain
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Last Update: 2020-06-22
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Source: Internet
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Author: User
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Spinal stimulation has been treating chronic back and leg pain for more than 50 years, but its efficacy is unstable and unpredictableResearchers have recently developed a new type of spinal stimulation system that provides live, real-time, continuous spinal cord activation indicators associated with efficacy by recording the induced compound action potential (ECAPs) during patients' daily useRecently, researchers examined the efficacy of closed-loop ECAP systems for pain relief in patientspatients with chronic, refractory back and leg pain participated in the study, randomly received ECAP feedback on closed-loop spinal cord stimulation or open-loop spinal stimulation with fixed output power (control group), and the primary endpoint of the study was the proportion of patients with a reduction of 50% or more overall back and leg pain134 patients participated in the study, 67 in each treatment groupAt 3 months, the proportion of the closed-loop group reaching the primary endpoint was significantly higher than that of the open-loop group (51 out of 62 patients , and 38 of the 63 patients , with a difference of 21.9 percent ) , and 36 ( 61.0% ) in 59 patients ( and 22.0% in 59 patients )There were no significant differences in security characteristics and adverse events between groupsstudies have shown that ECAP-controlled closed-loop stimulation can more effectively improve chronic back and leg painclinicalpain than open-loop spinal stimulation
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