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Stroke (stroke) is one of the main causes of disability.
Stroke (stroke) is one of the main causes of disability.
Survivors of stroke have an increased risk of cognitive impairment.
Approximately half of patients with post-stroke cognitive impairment (PSCI) develop in the first year after stroke.
Approximately half of patients with post-stroke cognitive impairment (PSCI) develop in the first year after stroke.
Lancet
In this large-scale multi-cohort lesion-symptom map study, the researchers aggregated and unified the individual patient data of 12 cohorts through the lesion-symptom map (Meta VCI Map) alliance.
PSCI is defined as a multi-domain neuropsychological assessment or Montreal Cognitive (MoCA) assessment, at least one cognitive domain performance is lower than 5% of the local normal data.
Voxel-based lesion-symptom mapping (VLSM) is used to calculate the voxel ratios (ORs) of PSCI.
Test flow chart
Test flow chartFor the PSCI risk prediction model, based on the results of VLSM, a 5-point position impact score is obtained.
A total of 2950 patient samples (mean age 66.
In general, infarctions in the left frontotemporal lobe, left thalamus, and right parietal lobe are closely related to PSCI.
Comprehensive model of PSCI predictor
Comprehensive model of PSCI predictorCross-validation shows that the performance of the position-affected score itself is similar to the comprehensive model with other PSCI predictors.
Cross-validation shows that the performance of the position-affected score itself is similar to the comprehensive model with other PSCI predictors.
In summary, this study is the first comprehensive model of the infarct brain area related to PSCI risk, which may be used by clinicians to identify individual patients at risk of PSCI in the future.
references:
Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts.
Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts.
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