Lancet Haematol: Prognosis for patients with endothelial lesions, clotting disease and new coronary pneumonia

Coagulation disease is an important feature of theofnew crown pneumonia, mainlythe risk ofthrombosis andcomplications ofblood vesselsPrevious studies have shown that endothelial cell damage plays a role inCOVID-19related clotting diseaseRecently, researchers assessed the difference seoktous cells and platelet activation markers in critical and non-critical patients hospitalizedin this single-center cross-sectional study, ICU and non-ICU COVID-19 patients participated in the studyAsymptomatic, non-resident control group was recruited as a biomarker control groupThe researchers assessed the participants' endothelial cells and platelet activation markers, including angiogenic hemophilia factor (VWF) antigens, soluble thrombosis-regulating proteins, soluble P-selectors and soluble CD40 ligands, coagulation factors, endogenous anticoagulants, and fibrosolutaseThe researchers compared differences in levels of each marker in ICU patients, non-ICU patients, and control groups and their effects on clinical outcomes, including discharge and mortality68 patients with COVID-19 participated in the study, including 48 icU patients and 20 non-ICU patients, and 13 non-hospitalized, asymptomatic control groups Compared to non-ICU patients, the levels of endothelial cells and platelet activation markers increased significantly in ICU patients, including VWF antigens (565% of ICU patients with an average of 278% in non-ICU patients) and soluble p-selectors (15.9 ng/mL vs 11.2 ng/mL) In 16 of the 20 non-ICU patients (80%) the concentration of VWF antigen was higher than the normal range The researchers found a significant correlation between patient mortality and the levels of VWF antigens (r-0.38; p-0.0022) and soluble thrombosis-regulating proteins (r-0.38; p-0.0078) In all patients, soluble thrombosis-regulated protein concentrations greater than 3.26 ng/mL were associated with lower discharge rates (88% of patients with low concentrations were discharged vs 52% dischargefrom high concentrations) 0), and were less likely to survive in Kaplan-Meier analysis (risk ratio 5.9) results showed that patients with COVID-19 had endothelial lesions and may be associated with critical illness and death Early detection of endothelial lesions and strategies to reduce their progression may improve the prognosis of PATIENTs with COVID-19