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Picture: The research was published on the back cover of "Lab on a Chip"
The intestinal epithelium of our body is composed of countless slender villi microstructures, which increase the total surface area of the inner wall to better absorb and digest nutrients
To this end, the Pohang University of Technology research team has recently developed an intestinal epithelial cell culture system that can simultaneously form a three-dimensional villi microstructure on a porous insertion platform
Professor Dun Jincheng and PhD candidate Beom Chong said that Jaeseung dreams of POSTECH and a research team led by a professor in the Department of Mechanical Engineering Hyun Jung Kim's University of Texas at Austin develops a multicultural system (basin) that can reproduce three-dimensional fluff formation Of humans also have intestinal epithelial cells
Traditional culture platforms, such as organ chips, have developed a three-dimensional villi structure that induces the morphogenesis of intestinal epithelial cells, and the function is similar to the actual intestine
The research group is committed to inducing the simultaneous morphogenesis of intestinal epithelial cells in various specimens, and is committed to developing an in vitro model similar to the actual structure and function of the intestine
The basin developed by the research team is a very simple system that only contains 24 commercial cell culture inserts, an orbital shaker commonly found in laboratories, and an open basal side cavity to allow convection to form
The results confirmed that the Caco-2 human intestinal epithelial cells cultured in BASIN grew in a three-dimensional structure similar to intestinal villi and showed a distribution of cell characteristics similar to actual intestinal villi
Professor Jin Dongcheng, who led the research, explained: “We have successfully demonstrated that the three-dimensional villi formation of intestinal epithelial cells can be replicated simultaneously in a variety of cell culture inserts, especially maximizing its compatibility with commercial products.
Article title
Multiplex recreation of human intestinal morphogenesis on a multi-well insert platform by basolateral convective flow
