Lab Invest: Expansion stress may enhance the growth and migration of breast cancer cells.

July 16, 2020 // In a recent study published in the international journal Laboratory Investigation, scientists from the University of Alabama and other institutions found that expansion stress may have a surprising effect on breast cancer cells by producing a condition that accelerates the risk of diseasePhoto Source: CC0 Public Domain As Breast Tumors Grow, biomechanical forces in the Tumor Microenvironment (TME) promote pressure and increased tension within the tumor, and can cause changes in fluid flow between tumor tissues, causing invasive growth, diffusion and metastasis of tumors, while biomechanics regulate the host body's immune response through crosstalk between cancer cells and immune cellsIn this study, researchers developed a new, tissue-engineered 3D breast cancer simulation systemThe system can describe the presence of tumor-related fibroblasts, endothelial cells and immune cells, in physiologically related extracellular matrix in the presence of breast cancer cells growth, the researchers found that biomechanical forces can significantly change the proteomic characteristics of breast cancer cells and enhance the production of exosomes, as a tumor micro-environment signal transducioning of an intercellular medium, tumor cells secreted by the exosome is now considered to be the key regulator of tumor progressionIn the study, the researchers found that exosomes can directly promote the growth of malignant tumor cells, and induce immunosuppressive response strains in tumor microenvironments and alter the polarization of immune cells, in addition, the researchers recently designed a vibration compression device that can apply biomechanical force to live primary breast tumors in real time, so that they can observe the exosome-mediated immunosuppressive effect and the growth of malignant tumors in miceFinally, the researchers said that a preliminary analysis of the migration of exosomes, the ingestion of immune cells and the polarization of the role may be superimposed into a new computer algorithm that can reveal the importance of exosome concentration gradients and time in predicting the kinetic dynamics of primary cancer genes, and can link the biomechanical forces of immune cells in the tumor microenvironment, the intake of exosomes released by tumor cells, and the intake and polarization processes of exosomesOriginal origins: Wang, Y., Goliwas, K.F., Severino, P.Eet alMStrain urges phenoty changepics in cancer and promots promots in the tumor-thanosLab Invest (2020)doi: 10.1038/s41374-020-0452-1.