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KRAS inhibitors combined with SHP2 inhibitors for the treatment of lung cancer Mirati and Sanofi reach an agreement

 Last Update: 2021-10-22
 Source: Internet
 Author: User

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On October 7, 2021, Mirati Therapeutics announced a clinical cooperation agreement with Sanofi

Adagrasib is a highly specific and potent oral KRAS G12C inhibitor, which has been optimized for long-lasting target inhibition

SAR442720 is a potent oral SHP inhibitor

▲SHP2 regulates the RAS signaling pathway (picture source: Revolution Medicines official website)

Because KRAS G12C inhibition and SHP2 inhibition have complementary mechanisms of action, they exhibit cumulative anti-tumor activity in preclinical models

Reference materials:

[1] Mirati Therapeutics to Collaborate with Sanofi on Phase 1/2 Study Evaluating Combination of adagrasib with a SHP2 Inhibitor in KRAS G12C-mutated Lung Cancer.

[1] Mirati Therapeutics to Collaborate with Sanofi on Phase 1/2 Study Evaluating Combination of adagrasib with a SHP2 Inhibitor in KRAS G12C-mutated Lung Cancer.
Retrieved October 8, 2021, from https://ir.
mirati.
com/press- releases/press-release-details/2021/Mirati-Therapeutics-to-Collaborate-with-Sanofi-on-Phase-12-Study-Evaluating-Combination-of-adagrasib-with-a-SHP2-Inhibitor-in-KRAS- G12C-mutated-Lung-Cancer/default.
aspx

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