Kiwifruit root has potential value for diabetes

According to a study completed by researchers from the school of chemistry and chemical engineering, Guizhou University, and the Key Laboratory of natural product chemistry, Chinese Academy of Sciences, Guizhou Province, on the effect of extracts from seven kinds of Guizhou Ethnic medicinal materials on the activity of α - glucosidase, the extract from kiwifruit root has a strong inhibition on α - glucosidase, which is stronger than acarbose, a positive drug, and further on the activity of α - glucosidase in kiwifruit root It was found that the activity of n-butanol was strong This shows that kiwifruit root has potential value in the research and development of diabetes α - glucosidase can degrade the polysaccharide in food into monosaccharide, which plays an important role in the internal metabolism of the body α - glucosidase is also involved in the biosynthesis and catabolism of glycolipids and glycoproteins in vivo, while diabetes, obesity, hyperlipidemia, inflammation, canceration, immune response and virus infection are closely related to the complex glycogen on the cell surface Therefore, α - glucosidase inhibitors can treat many diseases related to metabolism and virus infection In recent years, α - glucosidase inhibitors have been widely used to reduce postprandial hyperglycemia, which is one of the important measures to prevent diabetes, reduce diabetic complications and reduce mortality However, there are few kinds of α - glucosidase inhibitors, which are expensive and have some side effects Therefore, it has become one of the hot spots to search for high efficiency, low toxicity and low price α - glucosidase inhibitors at home and abroad The researchers selected 7 kinds of folk medicine trigonometry, balsam pear, three needles, smallpox powder, Pueraria lobata, Bambusa, kiwifruit root, which were used to treat diabetes or hepatitis and other diseases in Guizhou Province They extracted 7 kinds of medicine respectively by water extraction and alcohol precipitation, and then used in vitro α - glucosidase inhibitor screening model to inhibit α - glucosidase of 7 kinds of medicine extracts The activity was screened and compared with acarbose The results showed that there was little effect on the activity of α - glucosidase in the concentration range of 0.01-100 μ g / ml, or the inhibitory activity was weak In the same concentration range, kiwifruit root extract can inhibit the activity of α - glucosidase, and has a certain concentration dependence When the concentration is 100 μ g / ml, the inhibition rate can reach 96.2%, and the IC50 (half inhibition concentration) is about 1.55 μ g / ml When the concentration of acarbose was 1000 μ g / ml, the inhibition rate was 82.5%, and IC50 was about 175.97 μ g / ml The inhibitory effect of kiwifruit root extract on α - glucosidase is stronger than acarbose, indicating that kiwifruit root may have potential value for further research and development in the treatment of diabetes and other diseases The researchers then screened the effective parts of kiwifruit roots The results showed that the ethyl acetate and n-butanol parts of kiwifruit root had a strong inhibitory effect on α - glucosidase activity, and the activity of n-butanol part was the strongest, and its IC50 was 1.94 μ g / ml, which is worth further study However, the activity of the total ethanol extract of kiwifruit root is slightly higher than that of its n-butanol extract, which indicates that there may be synergistic effect of various components, and it suggests that the activity of the chemical components of Chinese herbal medicine is not necessarily stronger than that of the total extract after separation and purification Diabetes is the third serious threat to human health after cardiovascular disease and tumor Compared with insulin and other oral antidiabetic drugs, α - glucosidase inhibitor can effectively prevent postprandial blood glucose rise, maintain blood glucose at a certain level, reduce the stimulation of blood glucose on pancreas, and effectively prevent and improve the occurrence and development of diabetic complications In addition, α - glucosidase is also involved in the processing of key glycoproteins in the growth cycle of the virus Therefore, α - glucosidase inhibitors are also used in the treatment of viral diseases, such as AIDS and hepatitis At present, the research on the effect of Chinese herbal extracts on the activity of α - glucosidase is increasing gradually, and it has been found that some Chinese herbal extracts have different degrees of inhibition on α - glucosidase, but most of them are crude extracts of Chinese herbal medicine, but the specific active part of the substance basis (specific chemical composition) is not clear, and the mechanism of its pharmacological action is still insufficient 。 Therefore, it is of great significance to search for α - glucosidase inhibitors from Chinese herbal extracts and further extract and separate the active parts or active monomers under the guidance of activity.