Key proteins or important cells that can regulate bone structure

In a research report published in the international journal stem cell reports, scientists from the University of Wisconsin identified two special proteins in bone marrow through their research, which may be able to act as regulators of important cells for making bone marrow; Moreover, it can also regulate the activity of mesenchymal stem cells, and provide new ideas for later scientists to develop new implants to replace the damaged bone tissue of patients Professor Wan Ju Li, researcher, said the two proteins are very interesting molecules and play a key role in regulating the fate of mesenchymal stem cells In this paper, the researchers use high-throughput protein array to "wash" donated human bone marrow tissue to identify proteins of interest to the researchers, and then determine the activity of mesenchymal stem cells exposed to the identified proteins; The aim of the researchers is to better understand the bone marrow habitat of mesenchymal stem cells, so that later researchers can improve the cell growth environment in the laboratory and promote the development of disease therapy The researchers found that exposure of mesenchymal stem cells to a medium containing lipid carrier protein-2 and prolactin can reduce and slow down cell aging; Li said that in vitro we can control cell activity, but when it is implanted into the patient's body, it should slow down its growth and production of bone tissue In the laboratory, the ability to precisely control mesenchymal stem cells and maintain the balance of their division and formation of bone tissue provides a new clue for later researchers to reconstruct the missing bone tissue by using the three-dimensional matrix containing stem cells Because there are some natural healing characteristics of bone, for example, we can achieve self-healing of bone when fracture, but clinical intervention is very important when a large area of bone is missing To promote the growth of new bone in the body through regenerative medicine, we need to produce a large number of high-quality bone cells in the laboratory Stem cells are very rare in the body, but if we can control the growth, differentiation and quality of cells in the laboratory, researchers may be able to develop a large number of cells for treatment Now researchers have successfully implanted the bone regenerated from human cells treated with LPP-2 and prolactin into mice with skull cap defects At the same time, researchers also found that the new bone tissue has the ability to repair the defects of mice; In the future, they will further study to improve the culture environment of the laboratory, and the researchers hope to simulate the bone marrow habitat containing mesenchymal stem cells for research in the future