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Recently, in a new study published in Immunity, a research team led by Yale University in the United States used bioluminescence imaging technology to capture the transmission of SARS-CoV-2 (new coronavirus) in living animals for the first time, tracking the process of the virus from the nasal cavity of infected mice to the lungs, to other organs, and finally to the brain
。 The video image also monitors the real-time therapeutic effect of neutralizing antibodies, providing researchers with insight
into the effects of antibodies.
Priti Kumar, co-corresponding author of the study and associate professor of infectious diseases at Yale University School of Medicine, said: "We used to think that having neutralizing antibodies was enough to prevent infection, but now it seems that antibodies must be in the right place at the right time, and also need to be in sufficient titers
.
"So, in what other research areas is small animal in vivo imaging technology used? Lock in the compass biology live broadcast room on December 1 - small animal in vivo imaging technology open class will be introduced to you systematically, so stay tuned!
for modern biology, medicine and pharmaceutical research.
This topic of small animal in vivo imaging will explain the classification of small animal in vivo imaging, the basic principles and applications and practices of small animal in vivo optical imaging technology, and appropriately introduce the common problems of
small animal in vivo optical imaging technology.
Zheng, Director of Compass Biology Hangzhou Biology Laboratory, especially good at comparing sepsis and inflammatory models, pharmacology and toxicology experiments and efficacy evaluation
.
Participation in Project/Thesis 1 Zhejiang Provincial Natural Science Foundation Project and Zhejiang Provincial Administration of Traditional Chinese Medicine; 2.
ZHENG Jingru, JI Chunlian, ZHAN Lianghui, et al.
Effect and mechanism of trifolia in the treatment of sepsis based on network pharmacology and experimental verification[J].
Chinese Journal of Chinese Materia Medica: 1-13 3.
Zhan L, Zheng J, Meng J, Fu D, Pang L, Ji C.
Toll-like receptor 4 deficiency alleviates lipopolysaccharide-induced intestinal barrier dysfunction.
Biomed Pharmacother.
2022 Nov; 155:113778.
4.
Zhan L, Pu J, Zheng J, et al.
Tetrastigma hemsleyanum Diels et Gilg ameliorates lipopolysaccharide induced sepsis via repairing the intestinal mucosal barrier[J].
Biomed Pharmacother, 2022,148:112741.
5.
Zhan L, Liu H, Zheng J, Meng J, Fu D, Pang L, Ji C.
Electroacupuncture at Zusanli Alleviates Sepsis by Regulating the TLR4-MyD88-NF-Kappa B Pathway and Diversity of Intestinal Flora.
Evid Based Complement Alternat Med.
2022 Jun 10; 2022: 6706622.
Lecturer 2: Mr.
Jin, Chief Engineer of Compass Bioanimal Experimental Group, has been deeply engaged in the field of laboratory animal model construction, pathophysiology and neurology for more than eight years, and has rich practical experience
.
He is good at using disease model rats to conduct molecular and pathophysiological research on corneal diseases, and his research work involves the construction and verification
of animal models.
He is good at neuroscience disease behavior experimental verification and research
.
He has rich experience
in neuroscience disease behavior experimental verification and research.
Results of CCL4 and inflammation-related genes 2 Experimental results of natural small molecule nanodrug carrier development 3 Overview of courses on targeting of Cy5.
5-labeled drug-loaded nanoparticles in in vivo organs
.
A commonly used detection method is in vitro cytotoxicity assay (CCK8/MTT/CLSM, etc.
).
Cytotoxicity detection is a kind of biocompatibility test, to detect the toxicity of drugs or new materials in the biological environment, that is, to evaluate the toxicity or activity of drugs or materials by detecting the effect of materials or drugs on the proliferation or growth of cells, mainly used for drug activity screening, cell proliferation/toxicity determination, anti-tumor efficacy calculation IC50, etc.
; Commonly used MTT method or CCK8 method detection, in addition to Live/dead double staining method for cell imaging, more intuitive recording of cell survival
.
This course mainly explains the principles, methods, result analysis, and method applicability to comprehensively understand cytotoxicity experiments
.
Course catalog: (1) Biocompatibility introduction and detection methods (background, principle, practical application) (2) related operation procedures (3) data processing and result analysis (result judgment and interpretation) (4) interpretation
of common problems
Course 3: In vitro antibacterial experimental technology sharing (theory) Start time: December 15 Course
introduction: In vitro antibacterial test is in vitro determination of microorganisms on test objects (materials, Drugs, etc.
) sensitivity tests have been widely used in scientific research, production and clinical practice
.
Such as the screening of antibacterial drugs, the determination of antimicrobial spectrum, and the susceptibility test to guide clinical use
.
Bacterial infections contribute to high mortality and morbidity worldwide, and drug-resistant bacteria-associated infectious diseases kill more than 700,000 people worldwide each year, making them a major threat
to public health.
At present, antibacterial materials such as antibiotics or colloidal silver, photocatalytic materials, photothermal materials, etc.
are also popular clinical treatment strategies, and the selection of appropriate antibacterial detection methods is undoubtedly very important for the performance characterization of materials! Course Catalog: I.
Classification of in vitro antimicrobial experimental methods and their introduction II.
Introduction to biofilm and detection method III.
Implementation case sharing of photothermal/photocatalytic in vitro antibacterial detection IV.
How to choose the right antibacterial method for different materials V.
Common problems of in vitro antibacterial detection related
experimental needs can be scanned for consultation~
。 The video image also monitors the real-time therapeutic effect of neutralizing antibodies, providing researchers with insight
into the effects of antibodies.
Priti Kumar, co-corresponding author of the study and associate professor of infectious diseases at Yale University School of Medicine, said: "We used to think that having neutralizing antibodies was enough to prevent infection, but now it seems that antibodies must be in the right place at the right time, and also need to be in sufficient titers
.
"So, in what other research areas is small animal in vivo imaging technology used? Lock in the compass biology live broadcast room on December 1 - small animal in vivo imaging technology open class will be introduced to you systematically, so stay tuned!
1.
Course Theme
2.
Course introduction
for modern biology, medicine and pharmaceutical research.
This topic of small animal in vivo imaging will explain the classification of small animal in vivo imaging, the basic principles and applications and practices of small animal in vivo optical imaging technology, and appropriately introduce the common problems of
small animal in vivo optical imaging technology.
3.
Introduction by the lecturer
Zheng, Director of Compass Biology Hangzhou Biology Laboratory, especially good at comparing sepsis and inflammatory models, pharmacology and toxicology experiments and efficacy evaluation
.
Participation in Project/Thesis 1 Zhejiang Provincial Natural Science Foundation Project and Zhejiang Provincial Administration of Traditional Chinese Medicine; 2.
ZHENG Jingru, JI Chunlian, ZHAN Lianghui, et al.
Effect and mechanism of trifolia in the treatment of sepsis based on network pharmacology and experimental verification[J].
Chinese Journal of Chinese Materia Medica: 1-13 3.
Zhan L, Zheng J, Meng J, Fu D, Pang L, Ji C.
Toll-like receptor 4 deficiency alleviates lipopolysaccharide-induced intestinal barrier dysfunction.
Biomed Pharmacother.
2022 Nov; 155:113778.
4.
Zhan L, Pu J, Zheng J, et al.
Tetrastigma hemsleyanum Diels et Gilg ameliorates lipopolysaccharide induced sepsis via repairing the intestinal mucosal barrier[J].
Biomed Pharmacother, 2022,148:112741.
5.
Zhan L, Liu H, Zheng J, Meng J, Fu D, Pang L, Ji C.
Electroacupuncture at Zusanli Alleviates Sepsis by Regulating the TLR4-MyD88-NF-Kappa B Pathway and Diversity of Intestinal Flora.
Evid Based Complement Alternat Med.
2022 Jun 10; 2022: 6706622.
Lecturer 2: Mr.
Jin, Chief Engineer of Compass Bioanimal Experimental Group, has been deeply engaged in the field of laboratory animal model construction, pathophysiology and neurology for more than eight years, and has rich practical experience
.
He is good at using disease model rats to conduct molecular and pathophysiological research on corneal diseases, and his research work involves the construction and verification
of animal models.
He is good at neuroscience disease behavior experimental verification and research
.
He has rich experience
in neuroscience disease behavior experimental verification and research.
4.
Course Catalog
5.
Relevant in vivo imaging results
Results of CCL4 and inflammation-related genes 2 Experimental results of natural small molecule nanodrug carrier development 3 Overview of courses on targeting of Cy5.
5-labeled drug-loaded nanoparticles in in vivo organs
6.
Course Announcement
.
A commonly used detection method is in vitro cytotoxicity assay (CCK8/MTT/CLSM, etc.
).
Cytotoxicity detection is a kind of biocompatibility test, to detect the toxicity of drugs or new materials in the biological environment, that is, to evaluate the toxicity or activity of drugs or materials by detecting the effect of materials or drugs on the proliferation or growth of cells, mainly used for drug activity screening, cell proliferation/toxicity determination, anti-tumor efficacy calculation IC50, etc.
; Commonly used MTT method or CCK8 method detection, in addition to Live/dead double staining method for cell imaging, more intuitive recording of cell survival
.
This course mainly explains the principles, methods, result analysis, and method applicability to comprehensively understand cytotoxicity experiments
.
Course catalog: (1) Biocompatibility introduction and detection methods (background, principle, practical application) (2) related operation procedures (3) data processing and result analysis (result judgment and interpretation) (4) interpretation
of common problems
Course 3: In vitro antibacterial experimental technology sharing (theory) Start time: December 15 Course
introduction: In vitro antibacterial test is in vitro determination of microorganisms on test objects (materials, Drugs, etc.
) sensitivity tests have been widely used in scientific research, production and clinical practice
.
Such as the screening of antibacterial drugs, the determination of antimicrobial spectrum, and the susceptibility test to guide clinical use
.
Bacterial infections contribute to high mortality and morbidity worldwide, and drug-resistant bacteria-associated infectious diseases kill more than 700,000 people worldwide each year, making them a major threat
to public health.
At present, antibacterial materials such as antibiotics or colloidal silver, photocatalytic materials, photothermal materials, etc.
are also popular clinical treatment strategies, and the selection of appropriate antibacterial detection methods is undoubtedly very important for the performance characterization of materials! Course Catalog: I.
Classification of in vitro antimicrobial experimental methods and their introduction II.
Introduction to biofilm and detection method III.
Implementation case sharing of photothermal/photocatalytic in vitro antibacterial detection IV.
How to choose the right antibacterial method for different materials V.
Common problems of in vitro antibacterial detection related
experimental needs can be scanned for consultation~
