Keep away from toxic amino acids to prevent cardiovascular and cerebrovascular diseases

Without diabetes, high blood pressure, low cholesterol and normal blood lipid, why do you have a sudden stroke? Experts say that homocysteine, a "toxic amino acid" hidden in serum, is the real culprit of heart disease, stroke and peripheral vascular disease Homocysteine is a kind of heterotypic amino acid, which is a metabolite of human body When methionine in food protein provides important methyl groups for DNA, detoxification and other substances in human body, it will produce the intermediate product homocysteine, which will then be transformed into other important substances with physiological functions If the conversion process is blocked, homocysteine will stay in the blood The homocysteine in the blood not only has no nutritional effect, but also has strong cytotoxicity When its content in human body is more than 10 micromol, it is called hyperhomocysteinemia clinically, which is called "hyperhomocysteinemia" Professor Kong Juan, director of Clinical Nutrition Department of Shengjing Hospital Affiliated to China Medical University, said that homocysteine was called a more terrible substance than blood glucose and blood lipid, and it was a "toxic amino acid" If the content of homocysteine in the body is too high, it can cause the decrease of vascular elasticity, the rise of blood pressure, and the metabolic disorder of fat, sugar, protein and so on "It can also cause the rupture of the vascular endothelium, lead to the deposition of cholesterol in the vascular wall, and even make platelets adhere and gather, forming thrombus These conditions can lead to high blood pressure, stroke, myocardial infarction and other serious diseases It can be said that to some extent, the homocysteine value in the body can be regarded as the indicator and warning scale of cardiovascular and cerebrovascular diseases According to the international medical community, hyperhomocysteinemia is an independent risk factor for atherosclerosis and cardiovascular and cerebrovascular diseases: the normal content of homocysteine in the blood is only one thousandth of blood glucose and lipids, and a slight increase will cause more serious damage than hyperglycemia and hyperlipidemia Professor Sun Guifan, former director of chronic diseases research center of China Medical University, found that if the level of homocysteine can be effectively controlled, the death rate of chronic diseases can be reduced by 8.3%, which has more influence on death than diabetes and hyperlipidemia If the folate metabolism is not good, it may lead to the disorder of homocysteine metabolism Research shows that there is a significant negative correlation between the level of folic acid and homocysteine in the blood If the level of folic acid increases, the level of homocysteine will decrease correspondingly; if the folate gene mutation, the normal metabolism of homocysteine will be affected Experts say the risk of mutations in folate metabolism genes in Asians is higher than that in European and American populations, and homocysteinemia is more likely to occur "The study shows that the incidence rate of" high blood "is over 75% in China over 40 years old, and about 65% in women Kong Juan said Compared with severe hidden danger, it is relatively lack of cognition and attention It is understood that after Shengjing Hospital Affiliated to China Medical University opened the outpatient service of "high blood identity", more than 40 patients with "high blood identity" were screened in only three months Without exception, these patients did not know their homocysteine value was too high "Clinically, we found that about 75% of patients with hypertension will have homocysteinemia However, the current social awareness of this is not enough, many people do not take homocysteine test as a risk screening of cardiovascular and cerebrovascular diseases " Kong Juan said Kong Juan told reporters that the vast majority of patients with high homocysteine related cardiovascular and cerebrovascular diseases can be prevented when they die If it is found that the risk of "high blood content" is high through the screening of folate gene polymorphism, it is necessary to reduce the intake of smoking, drinking and coffee, increase the amount of exercise appropriately, supplement folate and folate bypass under the guidance of doctors, take betaine, compound B vitamins, etc (source: Economic Reference)