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Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder with greater variability in motor and nonmotor performance than previously thoug.
Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder with greater variability in motor and nonmotor performance than previously thoug.
Figure 1: Paper cover image
Figure 1: Paper cover imageSince the early 20th century, several studies have described the personalities of Parkinson's patients, which are typically characterized as rigid, introverted, over-controlling, cautious, reserved, punctual, serious, stoic, quiet, and hard-worki.
Since the early 20th century, several studies have described the personalities of Parkinson's patients, which are typically characterized as rigid, introverted, over-controlling, cautious, reserved, punctual, serious, stoic, quiet, and hard-worki.
According to this model, personality depends on two main characteristics: temperament and charact.
Compared with controls, PD patients had less novelty seeking and more harm avoidan.
However, most of the studies had small sample sizes, variable disease courses, and mainly included patients receiving dopaminergic drugs, so these studies do not provide a good picture of personality in the early stages of the disea.
With this, Bruna Meira et .
What they found: PD patients had low novelty seeking, high harm avoidance, and normal reward dependence and persistence scor.
Harm avoidance was positively associated with severity of depression, anxiety and apathy (rs = [435, 676], p < 001) and negatively associated with quality of life (rs = -492, p < 001.
Figure 2: The results of the paper
Figure 2: The results of the paperClassification of patients according to personality and PD symptoms found 3 distinct clusters:
Classification of patients according to personality and PD symptoms found 3 distinct clusters:1 - Neuropsychiatric phenotype (with high injury avoidance and low novelty seeking, low dopaminergic neuropsychiatric symptoms and higher impulsivity);
1 - Neuropsychiatric phenotype (with high injury avoidance and low novelty seeking, low dopaminergic neuropsychiatric symptoms and higher impulsivity);2- Athletic phenotype (with low novelty seeking and high exercise severity),
2- Athletic phenotype (with low novelty seeking and high exercise severity),3- Benign phenotype (with low harm avoidance and high novelty seeking, reward dependence and persistence traits clustered with lower symptom severity and low impulsivit.
3- Benign phenotype (with low harm avoidance and high novelty seeking, reward dependence and persistence traits clustered with lower symptom severity and low impulsivit.
The significance of this study lies in the discovery that the personalities of patients with early Parkinson's disease allow us to identify 3 patient phenotyp.
Original source:for the Honeymoon study group, Meira B, Lhommée E, et .
Original source:for the Honeymoon study group, Meira B, Lhommée E, et .
Early Parkinson's Disease Phenotypes Tailored by Personality, Behavior, and Motor Sympto.
J.
Published online May 4, 2022:1-1 doi:13233/JPD -21307 Early Parkinson's Disease Phenotypes Tailored by Personality, Behavior, and Motor Sympto.
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