echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Study of Nervous System > JPD: Parkinson's patients, often constipation, higher risk of cognitive decline

    JPD: Parkinson's patients, often constipation, higher risk of cognitive decline

    • Last Update: 2021-11-02
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    Untreated constipation is a common non-motor symptom (NMS) in Parkinson's disease (PD)


    Constipation may exist in all stages of Parkinson's disease, and may be a particularly disabling NMS in patients with advanced Parkinson's disease


    In addition, different studies have found that subjects with chronic constipation have a higher risk of PD, and constipation is considered a prodromal symptom of PD


    This link between constipation and Parkinson’s disease risk is thought to be related to the hypothesis of the gut-brain axis in the pathogenesis of Parkinson’s disease.


    New evidence suggests that the deposition of a-synuclein may begin in the enteric nervous system and then spread to the brain


    New evidence suggests that the deposition of a-synuclein may begin in the enteric nervous system and then spread to the brain


    They recruited PD patients and control groups in the COPPADIS cohort from 35 centers in Spain from January 2016 to November 2017




    The total score of PD-CRS of patients with constipation decreased significantly (from 89.


    In PD patients, constipation at stage V0 is associated with a decrease in the total score of PD-CRS


    The important significance of the study lies in the discovery; constipation is related to the cognitive decline of PD patients, but has nothing to do with the control group


    Constipation is related to the cognitive decline of PD patients, but has nothing to do with the control group




    Leave a message here
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.