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JPD: Neurofilament light chain protein predicts Parkinson's progression

 Last Update: 2022-02-19
 Source: Internet
 Author: User

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Parkinson's disease (PD) is a heterogeneous disease, both in terms of symptom presentation and the rate of disease progression
.

Methods are needed to predict how a person's disease will progress, which will aid research into the pathobiology of Parkinson's disease and potential disease-modifying treatments, and inform better patient decisions and personal care planning later in the disease basis

Neurofilament light chain (NfL) is a protein that is released from injured myeloid axes in various neurological diseases
.

NfL levels can differentiate PD from atypical parkinsonism

However, the applicability of these motor phenotypes in intermediate and advanced PD has been poorly studied, and there is the problem that as the disease progresses, a subset of patients are reclassified from the tremor-dominant to the PIGD motor phenotype
.

Recently, a clinical subtyping system that combines non-motor and motor assessments has been constructed

Hereby, Emil Ygland et al.
, Skane University Hospital, Sweden, investigated the prognostic value of S-NfL on PD-related and long-term outcomes
.

And hypothesized that combining S-NfL with PIGD-score or SCS-group could improve the accuracy of prognosis

They included 85 patients with PD duration of 7.
9±5.
1 years into the observation cohort
.

Clinical scores were obtained at two independent examinations 8.

They found: S-NfL levels showed significant hazard ratios for four of the five disease progression milestones: use of a walker (HR 3.
5; 95% CI 1.
4-8.
5), living in a nursing home (5.
1; 2.
1-12.
5) , end-of-motion (6.
2; 2.
1-17.
8), and death (4.
1; 1.
7-9.
7)
.

Higher S-NfL levels were associated with lower activities of daily living and worse cognitive performance at baseline and/or at follow-up
.

The combined model showed a significant improvement in the area under the receiver operating characteristic curve (0.

Pure S-NfL reflects motor and social outcomes later in PD

Original source:
Ygland Rödström E, Mattsson-Carlgren N, Janelidze S, Hansson O, Puschmann A.

Serum Neurofilament Light Chain as a Marker of Progression in Parkinson's Disease: Long-Term Observation and Implications of Clinical Subtypes.

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