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    Home > Active Ingredient News > Study of Nervous System > JPD: Does smoking and drinking increase the risk of Parkinson's?

    JPD: Does smoking and drinking increase the risk of Parkinson's?

    • Last Update: 2021-11-02
    • Source: Internet
    • Author: User
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    Parkinson's disease (PD) is considered a multifactorial disease involving genetic susceptibility and environmental factors


    It is inversely related to Parkinson's disease


    Mendelian randomization (MR) is an instrumental variable analysis that uses exposure-related genetic variants as a tool to estimate its causal relationship with disease


    However, the MR analysis of the elderly population may be biased due to survival bias.




    They used the inverse variance weighting method to calculate the probability of PD (ORIVW) and 95% confidence interval (CI)


    They found that there was a significant reverse association between initiation of smoking and PD (for every 1 percentage point increase in the prevalence of previous smoking, ORIVW=0.


    Participants ≤67 years of age had similar associations with cases ≤7 years


    In reverse MR, the heredity of PD has nothing to do with smoking or drinking coffee, but it is positively related to drinking


    The findings support the inverse association between smoking and PD, which is not explained by inverse causality, confounding factors, survival or morbidity bias


    This is not explained by reverse causality, confounding factors, survival or morbidity bias




    Mendelian Randomisation Study of Smoking, Alcohol, and Coffee Drinking in Relation to Parkinson's Disease.


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