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Apathy may be a core neuropsychiatric symptom of Parkinson's disease (P.
Apathy may be a core neuropsychiatric symptom of Parkinson's disease (P.
Figure 1: Paper cover image
Figure 1: Paper cover imageIn PD, frontal executive dysfunction due to intrinsic depletion of substantia nigra dopamine energy is expected to contribute to the development of apat.
In PD, frontal executive dysfunction due to intrinsic depletion of substantia nigra dopamine energy is expected to contribute to the development of apat.
Precise in vivo studies of neurotransmitter alterations in PD are challenging due to the complex logistics of PET imaging and possible interference with anti-Parkinsonian dru.
Notably, apathy reflects an underlying structural brain damage that extends beyond precortical regio.
In this way, Frederic Sampedroa et .
Furthermore, altered cortical DAT uptake resulted in cognitive impairment independent of the intrinsic striatal dopamine depletion that occurs in .
They hypothesized that apathy in patients with Parkinson's disease reflects a rather widespread pattern of dopaminergic exhaustion in cortical and subcortical brain regio.
In the Parkinson's Disease Progression Markers Initiative (PPMI) new-onset PD cohort, they performed whole-brain I123-Ioflupane single-photon emission computed tomography (DAT-SPECT) analysis to characterize the transection of DAT uptake associated with the presence of apathy Aspects and longitudinal differenc.
They found that apathetic PD patients (N = 70) had similar sociodemographic, clinical, and biomarker characteristics at baseline compared to the non-apathetic group (N = 33
However, during the four-year follow-up period, apathy was associated with an increased risk of developing cognitive impairment (P = 00
Figure 2: The results of the paper
Figure 2: The results of the paperApathetic patients showed a broad reduction in extrastriatal DAT uptake at baseline, as well as an increased longitudinal loss of DAT uptake compared with non-apathic patients (adjusted P < 05.
Apathetic patients showed a broad reduction in extrastriatal DAT uptake at baseline, as well as an increased longitudinal loss of DAT uptake compared with non-apathic patients (adjusted P < 05.
The significance of the study lies in the discovery that isolated Parkinson's disease patients are associated with extrastriatal dopaminergic degeneratio.
Original source:Sampedro,.
Original source:Sampedro,.
, Martínez-Horta,.
, Marín-Lahoz,.
, Pagonabarraga,.
, & Kulisevsky,.
(202
Apathy Reflects Extra-Striatal Dopaminergic Degeneration in de novo Parkinson's Disea.
_Journal of Parkinson's disease_, 13233/JPD-22322 Advance online publicati.
https://d.
org/13233/JPD-223223 Apathy Reflects Extra-Striatal Dopaminergic Degeneration in de novo Parkinson's Disea.
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