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Journal of stroke-After taking the thrombus from stroke, how about the safety and effectiveness of adjuvant treatment with fibrinase?

 Last Update: 2021-08-14
 Source: Internet
 Author: User

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For stroke, despite recent advances in technical efficacy, incomplete and failed reperfusion results are still an important issue

thrombus

Although the rate of cerebral infarction thrombolysis (TICI) level 3 reperfusion continues to increase, in more than half of the patients treated with MT, there is incomplete reperfusion or no reperfusion is established

However, the evaluation methods for symptomatic intracranial hemorrhage (symptomatic ICH, sICH) are inconsistent, and the relevant evidence is still limited for its therapeutic effect on reperfusion improvement

Regarding the inconsistent evaluation methods of symptomatic intracranial hemorrhage (symptomatic ICH, sICH), the relevant evidence is still limited for its therapeutic effect on the improvement of reperfusion

The study is based on INtra-arterial FIbriNolytics In ThrombectomY (INFINITY), which is a retrospective multi-center observation registry that records 10 European centers in patients with anterior circulation and major vessel occlusion and ischemic stroke receiving MT and IA fibrinolytic agents ( Adjuvant treatment of alteplase [Cathepsinogen Activator, TPA] or Urokinase [UK])

The main clinical outcome is based on the definition of the European Cooperative Acute Stroke Study II, symptomatic intracranial hemorrhage (symptomatic ICH, sICH)

The secondary results were mortality and modified Rankin Scale (mRS) scores at 3 months

Of the 5612 patients screened out, 311 (median age, 74 years; 44.

IA fibrinolytic agent is mainly used for the rescue of cerebral infarction (TICI) 0-2b after MT (80.

Among the tentative rescue patients of TICI0-2b, 116 of 228 patients (50.

116 of 228 patients (50.

Although IA fibrinolytic agents are rarely used as an adjuvant treatment of MT, they can improve reperfusion, which is related to better results

Original source

Kaesmacher J, Abdullayev N, Maamari B, et al.

Kaesmacher J, Abdullayev N, Maamari B, et al.
Safety and Angiographic Efficacy of Intra-Arterial Fibrinolytics as Adjunct to Mechanical Thrombectomy: Results from the INFINITY Registry.
J Stroke.
2021 Jan;23(1):91-102.
doi: 10.
5853/jos.
2020.
01788.
Epub 2021 Jan 31.
PMID: 33600706; PMCID: PMC7900401.

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