JNNP: The prognostic relationship of neurofilament, CHIT1, YKL-40 and MCP-1 in patients with amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the progressive loss of motor neurons in the brain, brainstem, and spinal cord
.

This can lead to progressive muscle weakness and weight loss

Cerebrospinal fluid (CSF) and neurofilaments (Nfs) in the blood have been shown to reflect the degree of motor neuron degeneration and predict the survival rate of patients with ALS (pALS)

Three neuroinflammation markers with good performance at the diagnostic and prognostic level of ALS were selected: chitotriosidase (CHIT1), chitinase 3-like protein 1 (YKL-40) and monocyte chemotactic protein (MCP) -1)

This article was published in " Journal of Neurology, Neurosurgery & Psychiatry " ( Journal of Neurology, Neurosurgery & Psychiatry ) This article was published in " Journal of Neurology, Neurosurgery & Psychiatry " ( Journal of Neurology, Neurosurgery & Psychiatry ) This article was published in theJournal of Neurology, Neurosurgery & Psychiatry(Journal of Neurology, Neurosurgery & Psychiatry)

PALS patients were recruited in two centers
.

Including sporadic ALS (sALS), ALS caused by repeated amplification of C9orf72 (C9-ALS) and asymp-C9

Similar results were also found when pNfH was combined with YKL-40 (Supplementary Figure 1 online)

The combination of NfL and YKL-40 levels predicts the survival rate of patients with amyotrophic lateral sclerosis
to further explore the relationship between these biomarkers in predicting survival, and incorporate these biomarkers into a model that contains eight established models Prognostic factors (medullary and non-bulbar onset, age of onset, presence of clear ALS, delay in diagnosis, forced vital capacity, progression rate, frontotemporal dementia (FTD) and the presence of repeat expansion of C9orf72
.

When included in this model, The increased level is independently related to the shorter survival rate of each biomarker

In short, although CHIT1 levels have a better correlation with Nfs, YKL-40 has the most significant added value to Nfs to predict the survival of pALS

MasroriP ,De SchaepdryverM ,FloeterMK MasroriPMasrori De SchaepdryverMDe Schaepdryver FloeterMKFloeter, et alJournal of Neurology, Neurosurgery & PsychiatryPublished Online First:15 December 2021.
 Published Online First: doi:10.
1136/jnnp-2021- 327877doi:leave a message here