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JNNP: The clinical spectrum of high-titer GAD65 antibodies

 Last Update: 2021-03-21
 Source: Internet
 Author: User

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Glutamate decarboxylase-65 (GAD65) is an enzyme required for the synthesis of γ-aminobutyric acid, which is a major central nervous system inhibitory neurotransmitter.

Diabetes Immunitymedsci.

In the submitted 380514 anti-GAD65 samples (2003-2018), 323 patients were identified with high titer (GAD65 antibody concentration in serum>20nmol/L) GAD65 antibody.

diagnosis

In the review, 108 patients were classified as not having GAD65 neurological autoimmunity, and 3 patients had no more likely alternative diagnosis, but had atypical manifestations (hyperactivity disorder).

Autism spectrum disorders Autism

In conclusion, the high titers of GAD65 antibodies suggest that the GAD65 nervous system is autoimmune.

BudhramA ,SechiE ,FlanaganEP BudhramABudhram SechiESechi FlanaganEPFlanagan, et albmj.

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