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JNNP: The circadian rhythm of the onset and progression in the central ischemic stroke area

 Last Update: 2021-06-01
 Source: Internet
 Author: User

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Understanding the determinants of the progression of acute cerebral infarction is critical to the optimal treatment of patients with large vessel occlusion (LVO) stroke and the design of randomized controlled trials.

Vascular Stroke

at night.

This article uses a meta-analysis of data from three independent and prospectively recruited cohorts of pre-LVO stroke patients to explore whether the central zone and penumbra volume on the ischemic side show a 24-hour ("circadian rhythm") rhythm.

Using univariate or multivariate linear regression analysis, the time of symptom onset is divided into three groups: "morning" (3:00-9:00 am) and "daytime" (9:00 am-3:00 pm) to discuss the image The circadian rhythm of the academic parameters is adjusted and analyzed according to age, start imaging time, collateral score and center adjustment.

Circadian rhythm of central area volume and growth after ischemic stroke

Analysis from three cohorts (Munich: N=314, Basel: N=155; Gottingen: N=114).

Therefore, for patients with nocturnal disease, the time of intravascular treatment and intravenous thrombolysis may be more important.

This article provides evidence for the circadian rhythm of the volume of the ischemic central area and the growth of the central area where the infarction progresses faster when the patients with nocturnal disease are admitted to the hospital.
Further research is needed to better understand the underlying pathophysiology and whether these rhythms also affect the efficacy of acute stroke treatment.
ReidlerP ,BrehmA ,SpornsPB ReidlerP Reidler BrehmA Brehm SpornsPB Sporns , et al bmj.
com/content/early/2021/05/25/jnnp-2021-326072" target="_blank" rel="noopener">Circadian rhythm of ischaemic core progression in human stroke Journal of Neurology, Neurosurgery & Psychiatry Published Online First: 26 May 2021.
Published Online First: doi: 10.
1136/jnnp-2021-326072 doi:

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