JNNP: Neuronal surface antibody syndrome is common in children with narcolepsy and motor disorders.

Type 1 narcolepsy (NT1) is a chronic sleep disorder that is suspected to be the cause of autoimmune disease.
in the children's group, there is a complex movement disorder, the clinical symptoms of which are typical of sudden oncology.
These movements are reminiscent of post-streptococcus autoimmune diseases and may be associated with Sydenham's disease, convulsions, and autoimmune neuropsychiaction in children with streptococcus infection (PANDAS) and the movement of patients with neurosurgery antigen antibodies (nsab).
study of movement disorders in NT1 patients.
: The authors evaluated patients who had been taking NT1 drugs continuously over the past year at the Bologna Sleep Center.
patients were diagnosed according to the third edition of the International Classification of Sleep Disorders (ICSD).
serum is stored at -80 degrees C.
study exercise phenomena and score retrospectively, the authors used video recordings from the day of routine blood sampling on their first hospitalization.
cell tests of specific antigens were performed on NT1 patients and control group serums.
58 patients aged 8-66 (median 32.5), 22 of whom were under the age of 18.
age (excessive drowsiness or collapse during the day) was 14.5 years (range 4-62).
: 49/58 (84.4%) of patients with emotional stimulation experienced abnormal movements.
24 cases showed only the movement phenomena associated with sudden inverting, such as segmentation or systemic stress loss, but 25 cases (43.1%) had "active" exercise, 19 cases were accompanied by negative phenomena, and 6 cases were isolated.
overall, "active" exercise was more frequent among children than among adults (14 children (63.6%), 11 adults (30.6%), p-0.017, and children's active (p-0.002) and negative (p-lt;0.0001) sports activity scored higher than that of adults.
in children, active exercise was associated with an acute onset (p-0.002) and a shorter duration of the disease at the time of examination (p-lt;0.0001).
8 out of 58 patients had specific antibodies.
4 serums combined with NMDAR, 1 with LGI1 and 3 with HCRTR2;
all other test antibodies (AMPAR, IgLON5, D2R, GABAAR, GlyR, GABABR, CASPR2) had a higher rate of NMDAR antibodies in children's narcolepsy control group than in 60 children with narcolepsy control groups (4/22 vs 0/60, p-0.004).
the hcrt-1 CSF level was normal in two HCRTR2 antibody-positive patients (p=0.022), one of the patients was HLA-negative, and the hcrt-1 CSF level in HCrt-1 antibody-positive patients in LGI1 antibody-positive patients was also negative (p=0.016).
presence of motor disorders can guide serum and cerebrospinal fluid antibody testing in children's narcolepsy prospective studies to confirm these new findings and consider their significance.
Giannoccaro MP, Pizza F, Jacobson L, et al Neuronal surface antibodies are common in children with narcolepsy and active movement disorders Journal of Neurology, Neurosurgery Psython Published Online First: 17 September 2020. doi:10.1136/jnnp-2020-323638MedSci Original Source: MedSci Original Copyright Notice: All notes on this website "Source: Met Medical" or "Source: MedSci Original" text, pictures and audio-visual materials, copyright owned by Mace Medical, not authorized by any media Websites or individuals may not be reproduced, and the authorizing reprints must include "Source: Metz Medicine".
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