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JNNP: Longitudinal tissue changes of spinal cord gray matter and white matter after spinal cord injury

 Last Update: 2021-08-14
 Source: Internet
 Author: User

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Spinal cord injury (SCI) is the damage to the structure and function of the spinal cord due to various pathogenic factors

Experimental studies have shown that the sensory and motor fascicles above and below the injury appear early anterograde and retrograde neurodegeneration

Longitudinal changes in the cross-sectional area of the spinal cord (A, B) and the cross-sectional areas of the spinal cord (SC), white matter (WM), and gray matter (GM)

Thirteen trauma patients and three non-traumatic SCI patients received continuous rehabilitation programs at the Bargrist University Hospital (Zurich, Switzerland) from January 2016 to March 2019, and ten healthy controls were recruited at the same time.

Diffusion tensor imaging (DTI) index difference 2 months after spinal cord injury

The cross-sectional tissue regions including spinal cord area (SCA), gray matter area (GMA) and white matter area (WMA) were extracted from these slices, and the average value was taken on the slices

Changes in the differences between C2/C3 and lumbar enlargement standardized white matter (WM) and gray matter (GM) regions in patients with spinal cord injury (SCI)

Of the 16 patients in the study, 8 were quadriplegic and 8 were paraplegic

Two months after the injury, the white matter area of the lumbar spine decreased by 8.

²²²²²²

In short, gray matter degeneration above the degree of injury is initially lower than that of white matter, but over time, it accelerates about 1.

In short, gray matter degeneration above the degree of injury is initially lower than that of white matter, but over time, it accelerates about 1.
5 years after spinal cord injury and reaches a similar degree of atrophy
.
Below the lesion, gray and white matter atrophy changes similarly
.
The clinicopathological link between early degenerative changes and function and nerve recovery confirms the results of this study
.
These results can be used to track the formulation of therapeutic interventions
.
DavidG ,PfyfferD ,VallottonK DavidG David PfyfferD Pfyffer VallottonK Vallotton , et al Longitudinal changes of spinal cord grey and white matter following spinal cord injury Journal of Neurology, Neurosurgery & PsychiatryPublished Online First:02 August 2021.
Online First: doi:10.
1136/jnnp-2021-326337 doi:

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