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Several large studies have examined the inheritance of Alzheimer's disease (AD)
.
Twin studies provide a unique opportunity to determine the relative importance of genetic and environmental factors
.
However, a major limitation of studying the genetic basis of AD is the heterogeneity that appears in the clinical phenotype
.
Another challenge is that AD is a multi-component disease
.
In addition, AD and cerebrovascular disease (SVD) pathology usually co-occur in the elderly, and have a variety of common vascular risk factors, including diabetes, middle-aged hypertension, obesity, and smoking
.
However, at the pathological level, whether brain SVD promotes amyloid pathology remains controversial
.
This article mainly studies: What is the heritability of cortical β-amyloid load in the global and specific brain regions? This article was published in "Neurology, Neurosurgery Psychiatry and" ( Journal of Neurology, Neurosurgery & Psychiatry ).
Participants were from the Australian Older Twins Study (OATS)
.
OATS is a community-based longitudinal study that studies the aging of twins 65 years of age or older registered with the Australian Twin Research Centre
.
Heritability of amyloid load
Detailed sociodemographic, clinical and neuropsychological data were collected for OATS participants
.
Some participants can obtain fasting blood pathology data, including fasting blood glucose (n=162) and fasting blood lipids (high-density lipoprotein, low-density lipoprotein, triglycerides and total cholesterol; n=163)
.
The study included 206 participants, including 61 pairs of MZ twins, average age: 71.
98 (SD 6.
43) years) and 42 pairs of DZ twins, average age: 71.
14 (5.
15) years)
.
Most people have no cognitive impairment
.
The study included a total of 206 participants, including 61 pairs of MZ twins, average age: 71.
Current research results indicate that the accumulation of β-amyloid protein is mostly affected by moderate genetic influences and is susceptible to major environmental factors
KonczR & lt ,ThalamuthuA ,WenW is KonczR & ltKoncz ThalamuthuAThalamuthu WenW isWen, et Alof The heritability of amyloid in older Adults Burden: The Older Australian Twins StudyJournal of.
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